An analysis of inhibitory mechanism of colonic carcinoma and hepatic metastasis by apple pectin

苹果果胶抑制结肠癌及肝转移的机制分析

• 批准号: 08671343
• 负责人: TAZAWA Kenji
• 金额: $ 1.41万
• 依托单位: TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671343/
• 关键词: Apple pectin; Dietary fiber; Hepatic metastasis; free radical; Carcinogeneses; pectin; Cancer prevention; アップル、ペクチン

Highly reactive oxygen-derived free radicals may play a role in carcinogenesis and hepatic metastasis. Free radical scavenging activity of apple pectin (Oligosaccharides and Oligogalacturonic acids) and components of Oligosaccharides used for the attenuation of colon carcinogenesis and hepatic metastasis, were investigated in vivo and in vitro. The used exprimental system was a radical scavenging action against superoxide anion radical and hydroxyl radical by the electron spin resonance technique. Oligosaccharides of apple pectin showed radical scavenging activity in a concentration-dependent manner in vitro, while on the han there are not significant in vivo. Components of Oligogalacturonic acids showed radical scabenging activity only in lowest molecular weight. The results indicate that the components of apple pection treated for prevention of carcinogenesis and metastasis were good radical scabenger that could possibly prevent the immune suppression of hepato-portal system.

高活性氧自由基可能在肿瘤的发生和肝转移中发挥作用。本实验研究了苹果果胶（寡聚果糖和寡聚半乳糖醛酸）及其组成成分在体内和体外对自由基的清除作用。采用电子自旋共振技术对超氧阴离子自由基和羟自由基进行了清除实验。苹果果胶低聚糖在体外表现出一定的清除自由基活性，且具有浓度依赖性，而在体内则无明显的清除自由基活性。低聚半乳糖醛酸组分仅在分子量最小的组分中表现出抗自由基活性。结果表明，苹果果胶中的抗癌转移成分是一种良好的根治剂，可能具有对抗肝门脉系统免疫抑制的作用。

项目成果

Tazawa K,Ohkami H et al: "Inhibitory effects of apple pectin on hepatic metastasis rat model." functional Foods:Overview and Diseuse Prevention. 1(in printce). (1998)

Tazawa K，Ohkami H 等：“苹果果胶对大鼠肝转移模型的抑制作用”。

K.Tazawa, H Okami et al: "Effect of Apple pectine on fecal emzyme activity and proslaglandin E_2 levels in Azoxymethame-induced rat colon" Proceeding of International Conference on Food Factors-Chemistay and Cancer Prevention. 1. 178-181 (1997)

K.Tazawa、H Okami 等人：“苹果果胶对偶氮甲肟诱导的大鼠结肠中粪便酶活性和前列腺素 E_2 水平的影响”国际食品因素-化学和癌症预防会议论文集。

K.Tazawa,H.Ohkami,I.Yamashita,Y,Ohnishi,M.Fujimaki: "Role of inflamination on AOM-induced rat colon carcinogenesis:Effects,of AApple pectine on AOM-induced colon carcihoma in rats" The 6th INternetional Symposium of the Sapporo Cancer Seminar. Abstrects.

K.Tazawa,H.Okami,I.Yamashita,Y,Ohnishi,M.Fujimaki：“炎症对 AOM 诱导的大鼠结肠癌发生的作用：苹果果胶对 AOM 诱导的大鼠结肠癌的影响”第六届国际研讨会

Tazawa K., Ohkami H., Yamashita I., Ohnishi Y., Kobashi K.M,Fujimaki M.: "Effect of apple pectin on Azoxymethane-induced colon carcinogenesis-Fecalenzyme activitics and prostaglandin E2 levels" Proceedings of International Conference on Food Factors-Chemi

Tazawa K.、Ohkami H.、Yamashita I.、Ohnishi Y.、Kobashi K.M、Fujimaki M.：“苹果果胶对氧化偶氮甲烷诱导的结肠癌的影响 - 粪便酶活性和前列腺素 E2 水平”国际食品因素会议论文集 -

Tazawa K., Ohkami H., Yamashita I., Ohnishi Y., Kobashi K., Fujimaki M.: "Effects of apple pection on fecal enzyme activities and prostaglandin E2 levels in Azoxymethane-induced rat colon carcinogenesis" In : Ohigashi H., Osawa T.eds.International Confere

Tazawa K.、Ohkami H.、Yamashita I.、Ohnishi Y.、Kobashi K.、Fujimaki M.：“苹果果酱对氧化偶氮甲烷诱导的大鼠结肠癌中粪便酶活性和前列腺素 E2 水平的影响” In : Ohigashi H.