A Study of Super-selective Hyperthermia Using Dextran Magnetite Particles

右旋糖酐磁铁矿颗粒超选择性热疗的研究

• 批准号: 03454299
• 负责人: TAZAWA Kenji
• 金额: $ 3.78万
• 依托单位: Toyama Medical & Pharmaceutical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03454299/
• 关键词: Inductive Heating; RF Heating; Super-selective Hyperthermia; Implant Heating; Combined Therapy; Dextran Magnetite Particles; VX-2 Tumor; Meth-A Tumor; デキストラン複合磁性体; 500kHz帯誘導加温法; 微小励起物質; VX2腫瘍細胞; 管腔臓器腫瘍モデル; VZ2腫瘍細胞

Hyperthermia is using clinically as the 5th treatment for cancer. But, it is difficult to heat cancer cells selectively. When heating deep seated tumors, it is difficult to identify the heated area and ignore damage for normal tissues. In previous study, we have reported selective hyperthermia using dextran magnetite particles (DM) and inductive heating method. In this study, a conversion of heating unit and some studies were investigated for clinical use (as follows).1) The power of heating unit has been increased to use clinically. The system has been set up to regulate automatically the temperature by a computer.2) The deep seated tumors of New Zealand white rabbits were established with VX-2 tumors (ex. liver, colon, and urinary bladder tumor). These tumors were heated by DM particles and inductive heating unit. The methods of heating were intratumorous injection method, balloon method, and intracavitary method. The inhibition of tumor proliferation was investigated in liver and urinary bladder tumor.3) Meth-A tumors of BALB/c mice were heated by combination with anticancer drug (MMC). The increased life span after treatment were observed in the group of hyperthermia and MMC.4) A new heating method with tubular implants were designed to heat deep seated tumor. The implants were polyester tube and filled up with DM aqueous sol. The temperature of an phantom with implants was measured in the inductive field. An area of 20 x 20 mm was heated with changing of power, number of implants, and arrangement.The selective heating of cancer was expected with use of the inductive heating at 500 kHx and DM particles. The possibility is expected of an application for the treatment of various cancer.

热疗在临床上被用作癌症的第五种治疗方法。但是，选择性地加热癌细胞是很困难的。当加热深部肿瘤时，很难识别加热区域并忽略对正常组织的损伤。在之前的研究中，我们报道了使用右旋糖酐磁铁矿颗粒（DM）和感应加热方法的选择性热疗。本研究对加热装置进行了改造，并进行了一些研究以供临床使用(如下)。1)增加了加热装置的功率以供临床使用。该系统已设置为通过计算机自动调节温度。2）用VX-2肿瘤（例如肝脏、结肠和膀胱肿瘤）建立新西兰白兔的深部肿瘤。这些肿瘤通过 DM 颗粒和感应加热装置加热。加热方法有瘤内注射法、球囊法、腔内法。研究了其对肝脏和膀胱肿瘤增殖的抑制作用。3)与抗癌药物(MMC)联合加热BALB/c小鼠的Meth-A肿瘤。在热疗组和MMC组中观察到治疗后寿命的延长。4)设计了一种新的管状植入物加热方法来加热深部肿瘤。植入物是聚酯管并且填充有DM水溶胶。在感应场中测量带有植入物的体模的温度。随着功率、植入物数量和排列的变化，对 20 x 20 mm 的区域进行加热。通过使用 500 kHx 的感应加热和 DM 颗粒，预计可以对癌症进行选择性加热。预计有可能应用于治疗各种癌症。

项目成果

竹森 繁ほか: "デキストラン・マグネタイト封入体を用いた癌温熱療法の試み" 第51回日本癌学会総会記事. 433 (1992)

Shigeru Takemori 等人：“使用葡聚糖磁铁矿包裹体进行癌症热疗试验”，第 51 届日本癌症协会年会文章，433 (1992)。

Kenji Tazawaほか(Edited by Eugene W.Gerner): "Proceedings of Sixth International Congress on Hyperthermic Oncology in Tuscon" Arizona Board of Regents, 501 (1991)

Kenji Tazawa 等人（由 Eugene W.Gerner 编辑）：“图森第六届国际热肿瘤学大会记录”，亚利桑那州董事会，501 (1991)

Shigeru Takemoriほか(Edited by Kaoru Sekiba): "Hyperthermic Oncology in Japan'90(Proceedings of 7th annual meeting)" Asahi Pronting & Publishing Co.,Ltd., 401 (1991)

Shigeru Takemori 等（关场薰编辑）：“Hyperthermic Oncology in Japan90（第 7 届年会记录）” Asahi Pronting & Publishing Co., Ltd.，401（1991）

Shigeru Takemoriほか(Edited by Rikisaburo Kamata): "Hyperthermic Oncology in Japan'91(Proceedings of 8th annual meeting)" Shinohara Publisher Inc., 420 (1992)

Shigeru Takemori 等人（蒲田力三郎编辑）：“日本的高温肿瘤学91（第 8 届年会记录）”筱原出版社，420（1992 年）

Kenji TAZAWA et al: "A study of inductive heating for cancer with use of dextran magnetite (II), effects for various cancer cells by intracellular hyperthermia" Japanese J.of Hyperthermic Oncology. 7(4). 381-390 (1991)

Kenji TAZAWA 等人：“使用葡聚糖磁铁矿 (II) 进行癌症感应加热的研究，细胞内热疗对各种癌细胞的影响”日本 J.of Hyperthermic Oncology。