Basic and Clinical Study on Artificial Vertebral Body and Artificial Intervertebral Disc.

人工椎体和人工椎间盘的基础与临床研究。

• 批准号: 62480316
• 负责人: KITAHARA Hiroshi
• 金额: $ 4.48万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-62480316/
• 关键词: Artificial vetebral body; Artificial intervertebral disc; Spine; Metastasis; Vertebral body replacement; 人工椎間板; 人工推体; 脊推; 推体置換; 人工推間板; 転移性腫瘍; 椎体置換術; 固定性

1. Artificial vertebral body (AVB)We made a new AVB. The safety and practicality were confirmed by mechanical test,endurance test, and animal experiment. An operation of vertebral body replacement using this AVB was performed on metastatic spinal tumor of lumbar spine.The new AVB is composed of five parts. They are inner rod, outer rod,ring,washer, and screw. The height of the AVB can be easily changed by revolving the ring after application to the spinal column. The specially designed plate-portion of the AVB is fixed into the bony groove of the vertebra using bone cement. The mechanical stability of the fixation is better than those of conventional methods.Specially made AVB for dogs were applied to canine 4th lumbar vertebrae to evaluate the stability using microradiograph. Newly formed bone tissue was found around the bone cement and endplates at 4 weeks after surgery. A thin fibrous tissue layer of 40micrometer in thickness was also obserbed. AVB's for human cervical spine were also used for 4th lumbar vertebra of monkey. AVB fixation was stable after 6months from operation. No metal powder nor ion release was found aroud AVB.In the endurance test, the AVB was not broken after 100000 vertical compression test with 3000N and after 100000 torsional tests with 20Nm.2.Artificial intervertebral disc (AID)We made new AID using cancellous screws for fixation of itself to vertebral body. Pull out tests on various types of screw were done and the screw with 1.8mm in pitch and 1.5mm in thread height showed maximum pull out force. We also made porous material using titanium mesh. Bone ingrowth occured into the mesh in rabbit femur but it didn't occured in dog's intervertebral discs.To confirm the safety and practicality of this AID, further experiment using bigger animal is necessary.

1.人工椎体（AVB）我们研制了一种新型的AVB。通过力学试验、耐久性试验和动物实验证实了其安全性和实用性。应用该AVB对腰椎转移瘤进行椎体置换术。它们是内杆、外杆、环、垫圈和螺钉。AVB的高度可以通过在应用于脊柱后旋转环来容易地改变。AVB的特殊设计的板部分使用骨水泥固定到椎骨的骨槽中。本实验将犬专用AVB固定于犬第4腰椎，用显微X线片观察其稳定性。术后4周，骨水泥和终板周围可见新生骨组织。还覆盖了厚度为40微米的薄纤维组织层。用于人颈椎的AVB也用于猴的第4腰椎。术后6个月AVB固定稳定。AVB周围无金属粉末或离子释放。在耐久性试验中，AVB在3000N的垂直压缩10万次和20Nm的扭转10万次后均未断裂。2.人工椎间盘（AID）我们研制了一种新型的人工椎间盘，采用松质骨螺钉将其固定在椎体上。对不同类型的螺钉进行了拔出试验，螺距为1.8mm，螺纹高度为1.5mm的螺钉拔出力最大。我们还使用钛网制作了多孔材料。在兔股骨中有骨长入，而在狗椎间盘中无骨长入，为证实该AID的安全性和实用性，还需要进一步的大动物实验。

项目成果

和久真一: 日本整形外科学会雑誌.

Shinichi Waku：日本骨科学会杂志。

Waku Shin-ichi: "Comparison of various mechanical fixation methods used for vertebral body replacement." Proceedings of 1987 Annual Meeting of Japanese Society for Orthopaedic Biomechanics. (JSOB). 9. 81-84 (1987)

Waku Shin-ichi：“用于椎体置换的各种机械固定方法的比较。”

和久真一: 整形外科バイオメカニクス.

Shinichi Waku：骨科生物力学。

石井猛: 日本癌治療学会誌. 22. 15-24 (1987)

Takeshi Ishii：日本癌症治疗学会杂志 22. 15-24 (1987)。

Waku Shin-ichi: "An experimental study on New Artificial Vertebral Body." The Journal of the Japanese Orthopaedic Association.

Waku Shin-ichi：“新型人工椎体的实验研究”。