The Role of Agricultural Chemicals in the Development of Biliary Tract Cancer

为了阐明农用化学物质在胆道癌发生中的作用，我们对胆石症患者的胆道化学物质排泄进行了研究。此外，采用BOP （n -亚硝基双（2-氧丙基）胺）诱导的叙利亚仓鼠胆道癌模型，研究了化学物质在实验致癌性中的促进作用。结果在人胆汁中检测到二乙醚家族除草剂CNP（4-硝基苯基2,4,6-三氯苯基醚）。还检测到微量的六氯化苯（BHC）和滴滴涕（DDT）。但在人胆汁中未检出二苯氧基家族除草剂MCPA（4-氯-2-甲基-苯氧基乙酸乙酯）。在实验研究中，MCPA促进了叙利亚仓鼠肝外胆管和肝内胆管非典型上皮的发育，这些上皮是由BOP诱导的。然而，MCPA并没有促进胆囊非典型上皮的发育。这些结果表明，农用化学品促进了胆道癌的发展，特别是在日本。

In order to clarify the role of agricultural chemicals in the development of the biliary tract cancer, the biliary excretion of the chemicals in patients with cholelithiasis was studied. In addition, the promoting activity of the chemicals in the experimental carcinogenesis was investigated using the model of BOP (N-nitrosobis (2-oxypropyl)-amine) induced biliary tract cancer in syrian hamsters.As the results, CNP (4-nitrophenyl 2,4,6-trichlorophenyl ether), a herbicide of di-ethylether family was detected in the human bile. Trace amounts BHC (Benzen hexachloride) and DDT (Dichloro-diphenyl-trichloroethane) were also detected. However, MCPA (4-chloro-2-methyl-phenoxy acetic acid ethylester), a herbicide of di-phenoxy family, was not detected in the human bile. In the experimental study, MCPA promoted the development of the atypical epithelium, which was induced by BOP, of the extra- and intrahepatic bile duct in syrian hamsters. However, MCPA did not promote the development of the atypial epithelium of the gallbladder.These results suggested that the agricultural chemicals promote the development of carcinoma of the biliary tract especially in Japan.