The Role of Agricultural Chemicals in the Development of Biliary Tract Cancer

为了阐明农药在胆道癌发生发展中的作用，对胆石症患者胆汁中农药的排泄进行了研究。此外，利用BOP(N-亚硝基(2-氧丙基)胺)诱发叙利亚仓鼠胆道癌的模型研究了这些化合物在实验性致癌中的促癌活性。结果在人胆汁中检测到二乙醚类除草剂CNP(4-硝基苯基2，4，6-三氯苯醚)。此外，还检测到了痕量六六六和滴滴涕。但在人体胆汁中未检出二苯氧基类除草剂4-氯-2-甲基苯氧基乙酸乙酯。在实验研究中，MCPA促进了BOP诱导的叙利亚金黄地鼠肝内外胆管异型上皮的发育。然而，MCPA并没有促进胆囊异型上皮的发育。这些结果表明，农用化学品促进了胆道癌的发展，特别是在日本。

In order to clarify the role of agricultural chemicals in the development of the biliary tract cancer, the biliary excretion of the chemicals in patients with cholelithiasis was studied. In addition, the promoting activity of the chemicals in the experimental carcinogenesis was investigated using the model of BOP (N-nitrosobis (2-oxypropyl)-amine) induced biliary tract cancer in syrian hamsters.As the results, CNP (4-nitrophenyl 2,4,6-trichlorophenyl ether), a herbicide of di-ethylether family was detected in the human bile. Trace amounts BHC (Benzen hexachloride) and DDT (Dichloro-diphenyl-trichloroethane) were also detected. However, MCPA (4-chloro-2-methyl-phenoxy acetic acid ethylester), a herbicide of di-phenoxy family, was not detected in the human bile. In the experimental study, MCPA promoted the development of the atypical epithelium, which was induced by BOP, of the extra- and intrahepatic bile duct in syrian hamsters. However, MCPA did not promote the development of the atypial epithelium of the gallbladder.These results suggested that the agricultural chemicals promote the development of carcinoma of the biliary tract especially in Japan.