The Role of Agricultural Chemicals in the Development of Biliary Tract Cancer

农用化学品在胆道癌发展中的作用

• 批准号: 63480300
• 负责人: YOSHIDA Keisuke
• 金额: $ 4.16万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-63480300/
• 关键词: agricultural chemicals; gallbladder cancer; bile duct cancer; experimental carcinogenesis; BOP; MCPA; CNP; promoting activity; 体内残留農薬; 胆道癌; ブロモ-タ-作用; 化学発癌

In order to clarify the role of agricultural chemicals in the development of the biliary tract cancer, the biliary excretion of the chemicals in patients with cholelithiasis was studied. In addition, the promoting activity of the chemicals in the experimental carcinogenesis was investigated using the model of BOP (N-nitrosobis (2-oxypropyl)-amine) induced biliary tract cancer in syrian hamsters.As the results, CNP (4-nitrophenyl 2,4,6-trichlorophenyl ether), a herbicide of di-ethylether family was detected in the human bile. Trace amounts BHC (Benzen hexachloride) and DDT (Dichloro-diphenyl-trichloroethane) were also detected. However, MCPA (4-chloro-2-methyl-phenoxy acetic acid ethylester), a herbicide of di-phenoxy family, was not detected in the human bile. In the experimental study, MCPA promoted the development of the atypical epithelium, which was induced by BOP, of the extra- and intrahepatic bile duct in syrian hamsters. However, MCPA did not promote the development of the atypial epithelium of the gallbladder.These results suggested that the agricultural chemicals promote the development of carcinoma of the biliary tract especially in Japan.

为了阐明农业化学物质在胆道癌发展中的作用，研究了化学物质在胆石症患者中的胆汁排泄。 In addition, the promoting activity of the chemicals in the experimental carcinogenesis was investigated using the model of BOP (N-nitrosobis (2-oxypropyl)-amine) induced biliary tract cancer in syrian hamsters.As the results, CNP (4-nitrophenyl 2,4,6-trichlorophenyl ether), a herbicide of di-ethylether family was detected in the human bile.还检测到痕量量BHC（苯并六氯化物）和DDT（二氯二苯基 - 三氯乙烷）。然而，在人类胆汁中未检测到MCPA（4-氯-2-甲基 - 苯氧基乙氧基乙酸乙酸乙酸乙酸），这是二苯氧家族的除草剂。在实验研究中，MCPA促进了由BOP诱导的非典型上皮的发展，叙利亚仓鼠的肝外胆管和肝内胆管的发展。但是，MCPA并未促进胆囊的非典型上皮的发展。这些结果表明，农业化学物质促进了胆道癌的发展，尤其是在日本。

项目成果

川口英弘: 日消外会誌. 21. 1253-1258 (1988)

川口秀宏：日州外会杂志 21. 1253-1258 (1988)

内田克之: 消化器外科. 12. 19-30 (1989)

内田胜幸：胃肠外科。12. 19-30 (1989)

篠川主: 新潟医学会雑誌. 103. (1989)

筱川，M.：新泻医学会杂志 103。（1989）

吉田奎介: がん治療のあゆみ. 7. 145-153 (1988)

Keisuke Yoshida：癌症治疗史。7. 145-153 (1988)。