The Role of Agricultural Chemicals in the Development of Biliary Tract Cancer

农用化学品在胆道癌发展中的作用

• 批准号: 63480300
• 负责人: YOSHIDA Keisuke
• 金额: $ 4.16万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-63480300/
• 关键词: agricultural chemicals; gallbladder cancer; bile duct cancer; experimental carcinogenesis; BOP; MCPA; CNP; promoting activity; 体内残留農薬; 胆道癌; ブロモ-タ-作用; 化学発癌

In order to clarify the role of agricultural chemicals in the development of the biliary tract cancer, the biliary excretion of the chemicals in patients with cholelithiasis was studied. In addition, the promoting activity of the chemicals in the experimental carcinogenesis was investigated using the model of BOP (N-nitrosobis (2-oxypropyl)-amine) induced biliary tract cancer in syrian hamsters.As the results, CNP (4-nitrophenyl 2,4,6-trichlorophenyl ether), a herbicide of di-ethylether family was detected in the human bile. Trace amounts BHC (Benzen hexachloride) and DDT (Dichloro-diphenyl-trichloroethane) were also detected. However, MCPA (4-chloro-2-methyl-phenoxy acetic acid ethylester), a herbicide of di-phenoxy family, was not detected in the human bile. In the experimental study, MCPA promoted the development of the atypical epithelium, which was induced by BOP, of the extra- and intrahepatic bile duct in syrian hamsters. However, MCPA did not promote the development of the atypial epithelium of the gallbladder.These results suggested that the agricultural chemicals promote the development of carcinoma of the biliary tract especially in Japan.

为了阐明农药在胆道癌发生发展中的作用，对胆石症患者胆汁中农药的排泄进行了研究。此外，利用BOP（N-nitrosobis（2-oxypropylene）-amine）诱发叙利亚仓鼠胆道癌模型，研究了化合物的促癌活性，结果在人胆汁中检测到乙醚类除草剂CNP（4-nitrophenyl 2，4，6-trichlorophenyl ether）。还检测到痕量的BHC（六六六）和DDT（二氯二苯基三氯乙烷）。而二苯氧基类除草剂MCPA（4-氯-2-甲基苯氧基乙酸乙酯）在人胆汁中未检出。在实验研究中，MCPA可促进BOP诱导的叙利亚仓鼠肝内外胆管非典型上皮的发育。但MCPA对胆囊上皮的发育无促进作用，提示农药对胆道癌的发生有促进作用，尤其是在日本。

项目成果

川口英弘: 日消外会誌. 21. 1253-1258 (1988)

川口秀宏：日州外会杂志 21. 1253-1258 (1988)

内田克之: 消化器外科. 12. 19-30 (1989)

内田胜幸：胃肠外科。12. 19-30 (1989)

吉田奎介: がん治療のあゆみ. 7. 145-153 (1988)

Keisuke Yoshida：癌症治疗史。7. 145-153 (1988)。

篠川主: 新潟医学会雑誌. 103. (1989)

筱川，M.：新泻医学会杂志 103。（1989）