Redox regulation of mitochondrial functions: from molecular basis to physiological response

众所周知，植物线粒体的氧化还原状态会随着环境刺激而波动，但在这种条件下线粒体功能是如何调节的，这在很大程度上是未知的。我筛选了在氧化还原调节中起关键作用的硫氧还蛋白（Trx）的线粒体靶蛋白，并提供了氧化还原调节候选蛋白的列表。利用生物化学和生理学的方法，研究了线粒体氧化还原调控系统的分子基础和生理反应。通过这些研究，我揭示了线粒体中的几个关键蛋白受到trx依赖性氧化还原调控。

Redox state of plant mitochondria is known to fluctuate in response to environmental stimuli, but it is largely unknown how mitochondrial functions are regulated under such conditions. I screened mitochondrial target proteins of thioredoxin (Trx) that plays a pivotal role in redox regulation, and provided a list of redox-regulated protein candidates. Furthermore, using biochemical and physiological approaches, I examined molecular basis and physiological responses of redox regulation system in mitochondria. By these studies, I revealed that several key proteins in mitochondria is subjected to Trx-dependent redox regulation.