Pharmacological studies on central nervous control systems in gastric acid secretion and on their signal tranduction systems.

从药理学的角度研究了胃酸分泌的中枢神经控制系统及其信号转导系统与食欲控制和胃溃疡治疗的关系，并研究了食欲控制物质降钙素对脑-肠相互作用的影响。降钙素通过中枢机制对胃酸分泌有明显的抑制作用，其作用与吗啡抑制胃酸分泌的作用类似，与中枢神经系统的兴奋机制密切相关。在戊巴比妥的作用机制中，中枢GABA机制有重要贡献，我们前期的研究发现，TRH和GABA可刺激胃酸分泌，作为脑抑制剂。 ...更多信息 y改良剂。在这方面，研究了几种用于治疗脑功能不全的药物对胃酸分泌的影响。发现霍潘顿酸钙、γ-氨基-β-羟基丁酸和胞胆碱对胃酸分泌具有明显的刺激作用。从这些结果可以看出，胃酸分泌可能与脑代谢状态有关。我们研究了几种谷氨酸受体激动剂对胃酸分泌的影响。红藻氨酸有显著的兴奋作用，谷氨酸和NMDA的作用较弱，但使君子酸无此作用。这些新颖的发现将促进这一领域的进一步研究。我们发现几种三环类抗抑郁药相关化合物对胃酸分泌有较强的抑制作用。除上述研究结果外，本研究还成功构建了脑肠失衡性胃溃疡动物模型，初步实现了本研究的计划。少

Central nervous control systems and their signal transduction systems in gastric acid secretion were investigated in relation to appetite control and gastric ulcer therapy on the basis of pharmacology.In relation to brain-gut interaction, the effect of an appetite control substance, calcitonin was studied. A remarkable depressive effect of calcitonin on gastric secretion via central mechanisms was found. Close interaction with central serotonergic mechanisms with the action of calcitonin was confirmed similar to the inhibitory effect of morphine on gastric acid secretion.In the course of the present study, we occasionally found that a general anesthetic, pentobarbital has a strong stimulatory effect on gastric acid secretion in the urethan anesthetized rats. In the mechanism of action of pentobarbital, the important contribution of central GABA mechanism was found.In our previous study, TRH and GABA were found to stimulate gastric acid secretion which are used as the brain insufficienc … More y improver. In this connection, the effects of several drugs used for cerebral insufficiency were investigated on gastric acid secretion. Hopantenate Ca^<2+>, gamma-amino-beta-hydroxy butyrate and citicholine were found to possess distinctive stimulatory effects on gastric acid secretion. From the present results, a possibility was suggested that, in some aspect, brain metabolic state may reflect on gastric acid secretion.In relation to GABA, we investigated the effect of some glutamate agonists on gastric secretion. A remarkable stimulatory effect of kainic acid was found as well as weak effects of glutamic acid and NMDA, but not of quisqualate. These quite novel findings will stimulate further investigation in this field. We found the strong inhibitory effect of several tricyclic antidepressant related compounds on gastric acid secretion. In addition to the above mentioned results, we succeeded to device new gastric ulcer models for the brain-gut imbalance diseases.In total, our research project plan was successfully achieved. Less