IL-11 as a novel parietal cell cytokine that blocks gastric acid secretion and causes gastric atrophy

2010年，全球将有100万人死于胃癌，而在西方世界，受胃癌影响的人数正在减少，而在发展中国家，情况正好相反，因此增加了全球健康负担。胃萎缩是胃癌发生前的一种病理状态。这个项目的目的是发展我们对导致萎缩发展的起始事件的认识，从而在它变成癌症之前告诉我们治疗这种疾病的新方法。

Stomach cancer will kill a million people in the world in 2010, while in the western world the numbers of affectd indiviuduals are decreasing while in the in the developing world the opposite is the thus adding to the global health burden. Gastric atrophy is a pathological condition that always preceeds gastric cancer. This project aims to devlop our knowledge of the intitating events that allow atrophy to develop, thus informing us of novel ways of treating this condition before it bcomes cancerous.