Expression of Cytokeratins in Odontogenic Tumors.

细胞角蛋白是上皮细胞特有的中间纤维，与上皮细胞分化密切相关。也就是说，在上皮细胞类型中已经描述了细胞角蛋白的不同组成对表达的分化特异性。沿着这些途径，细胞角蛋白在牙源性上皮中的表达被观察到，并特别参考牙胚与牙源性囊肿和肿瘤的关系进行了分析。但由于细胞角蛋白在牙源性肿瘤中的异质表达，细胞角蛋白的分布不太可能令人满意地解释牙源性肿瘤的起源。成釉细胞瘤;有趣的是，它们在滤泡型和丛状型之间存在细胞角蛋白分布的差异。在滤泡性成釉细胞瘤中，中心部分对细胞角蛋白、SE-K、NSE-K和K19的所有标记物均表现出免疫反应性。排列在外围的柱状细胞对K19反应较阳性，对NSE-K反应较弱，对鳞状细胞标志物SE-K反应较阴性。在丛状成釉细胞瘤中，中央和外周细胞均表现出SE-K、NSE-K和K19.2的阳性反应。腺瘤样牙源性肿瘤；腺瘤样牙源性肿瘤在中心区由柱状细胞组成，周围区由小圆形细胞组成。大部分中心细胞呈轮状结构或实巢状，鳞状细胞标志物SE-K不表达，少数区域呈微弱阳性。NSE-K和K19的免疫反应性是异质的，在中心区域存在免疫反应区和非反应区。导管或管状结构对鳞状细胞标志物（SE-K）也没有免疫反应，而对NSE-K和K19有阳性反应。中心轮状结构周围的细胞比中心柱状细胞小，增殖无组织模式。这些外周细胞对所有细胞角蛋白标记物均呈阳性反应。腺瘤样牙源性肿瘤中常见的网状小圆细胞区也与周围细胞角蛋白分布相同。珐琅器官；随着牙板向牙釉质器官的成熟，鳞状分化标志物SE-K的免疫反应呈负反应。NSE-K和K19在牙釉质器官中表现良好。少

Cytokeratins, intermediate filaments characteristic of epithelial cells, are well known to be closely related to epithelial differentiation. That is, the differentiation specificity to expression of different composition of cytokeratins has been described in epithelial cell types. Along these approaches, the expression of cytokeratins has been observed in the odontogenic epithelium and analyzed with special reference to the relationship between tooth germs and odontogenic cysts and tumors. But the distribution of cytokeratins has been unlikely to explain satisfactorily the origin of odontogenic tumors, because of heterogenous expression of cytokeratins in odontogenic tumors.1.Ameloblastoma ; Interestingly, they presented difference of cytokeratin distribution between follicular and plexiform types. In follicular ameloblastomas, the central portion showed immunoreactivity with all markers of cytokeratins, SE-K, NSE-K and K19. But the columnar cells arranged in the periphery were reacted … More positively for K19, faintly reacted for NSE-K, and negatively responded for the marker of squamous cells, SE-K. In plexiform ameloblastoma both central and peripheral cells demonstrated the positive reaction with all markers, SE-K, NSE-K and K19.2.Adenomatoid Odontogenic Tumors ; Adenomatoid odontogenic tumors demonstrated different distribution between central areas composed of columnar cells and peripheral areas of small round cells. Most areas of central cells, showing whorled structure or solid nests, demonstrated no expression for the marker of squamous cells, SE-K, however, only a few areas showed faint positivity. The immunoreactivity for NSE-K and K19 was so heterogenous that both immunoreactive and non-reactive areas were present within the central area. Ductal or tubular structures also showed no immunoreactivity for the marker of squamous cells (SE-K) with positive reaction for NSE-K and K19. The cells surrounding central whorled structures were smaller than central columnar cells and were proliferated without organizing pattern. These peripheral cells showed positive reaction for all markers of cytokeratins. Areas of reticular pattern composed of small round cells, which was frequently found in adenomatoid odontogenic tumors, also showed the same cytokeratin distribution with peripheral cells.3.Enamel Organ ; Along the maturation to enamel organ from dental lamina, the immunoreaction for the marker of squamous differentiation, SE-K, was negatively reacted. NSE-K and K19 were well demonstrated in the enamel organ proper. Less