Replacement purchase for a 800 MHz NMR spectrometer

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The research groups at the BNMRZ employ NMR spectroscopy to obtain molecular and mechanistic insight for essential biological processes that underlie physiological and diseaselinked cellular processes. The application involves an 800 MHz NMR spectrometer which will be employed for solution-state as well as MAS solid-state NMR. Research topics involve the analysis of protein structure and dynamics of amyloid fibrils, membrane proteins and virus assemblies. In solution, membrane protein nanodisc assemblies, protein-RNA and proteinchaperone complexes are investigated. An additional focus area is the development of methods for solution-state and MAS solid-state NMR.