Replacement purchase for a 800 MHz NMR spectrometer

BNMRZ的研究小组采用NMR光谱学来获得生理和疾病相关细胞过程基础的基本生物过程的分子和机制见解。该应用涉及一个800 MHz NMR光谱仪，将用于溶液状态以及MAS固态NMR。研究课题涉及淀粉样纤维、膜蛋白和病毒组装体的蛋白质结构和动力学分析。在溶液中，膜蛋白纳米盘组件，蛋白质-RNA和蛋白伴侣复合物进行了研究。另一个重点领域是开发溶液状态和MAS固态NMR的方法。

The research groups at the BNMRZ employ NMR spectroscopy to obtain molecular and mechanistic insight for essential biological processes that underlie physiological and diseaselinked cellular processes. The application involves an 800 MHz NMR spectrometer which will be employed for solution-state as well as MAS solid-state NMR. Research topics involve the analysis of protein structure and dynamics of amyloid fibrils, membrane proteins and virus assemblies. In solution, membrane protein nanodisc assemblies, protein-RNA and proteinchaperone complexes are investigated. An additional focus area is the development of methods for solution-state and MAS solid-state NMR.