Replacement purchase for a 800 MHz NMR spectrometer

更换购买 800 MHz NMR 波谱仪

• 批准号: 441546624
• 金额: --
• 依托单位: Technische Universität München (TUM)
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/441546624?language=en
• 关键词: Replacement; purchase; 800; MHz; NMR

The research groups at the BNMRZ employ NMR spectroscopy to obtain molecular and mechanistic insight for essential biological processes that underlie physiological and diseaselinked cellular processes. The application involves an 800 MHz NMR spectrometer which will be employed for solution-state as well as MAS solid-state NMR. Research topics involve the analysis of protein structure and dynamics of amyloid fibrils, membrane proteins and virus assemblies. In solution, membrane protein nanodisc assemblies, protein-RNA and proteinchaperone complexes are investigated. An additional focus area is the development of methods for solution-state and MAS solid-state NMR.

BNMRZ的研究组采用NMR光谱法获得了基本生理和疾病疾病细胞过程的基本生物学过程的分子和机械见解。该应用涉及800 MHz NMR光谱仪，该光谱仪将用于溶液状态以及MAS固态NMR。研究主题涉及分析蛋白质结构和淀粉样蛋白原纤维，膜蛋白和病毒组件的动力学。在溶液中，研究了膜蛋白纳米激体组件，蛋白-RNA和蛋白机酮络合物。另一个重点是开发解决方案状态和MAS固态NMR的方法。