Acquisition of 800 MHz NMR System with Cryogenic Probe

描述（由申请人提供）：这是申请800 MHz核磁共振（NMR）系统的部分资金，带有低温探针，用于生物分子和结构蛋白质组学研究。馀额将由机构配合基金、产业赠予及其他已为此目的批准的奖助金组合提供。配有低温探针的800 MHz核磁共振系统将主要用于蛋白质和核酸结构和动力学的研究，作为主要由美国国立卫生研究院支持的研究的一个组成部分。该仪器将被安置在一个新的2000平方英尺的生物分子核磁共振设施中，该设施最近由新泽西医学和牙科大学（UMDNJ）的罗伯特伍德约翰逊医学院（RWJMS）建造，主要由RWJMS和罗格斯大学的教师和科学家使用，包括高级生物技术和医学中心的成员，新泽西癌症研究所，霍华德休斯医学研究所，综合蛋白质组学技术中心，以及DIMACS数量生物学研究所。此外，800 MHz核磁共振仪器将提供给康奈尔大学、俄克拉荷马州立大学、内布拉斯加州大学、堪萨斯大学、佛蒙特大学以及新泽西州当地制药和生物技术公司的研究人员。最后，该仪器将用于支持由美国国立卫生研究院资助的东北结构基因组学联盟在高通量蛋白质结构生产方面的研究。

DESCRIPTION (provided by applicant): This is to request partial funding for an 800 MHz nuclear magnetic resonance (NMR) system, with cryogenic probe, for biomolecular and structural proteomics research. The balance of funding will be provided from a combination of institutional matching funds, industrial gifts, and other grant funds that have already been approved for this purpose. The 800 MHz NMR System with cryogenic probe will be used primarily for studies of protein and nucleic acid structure and dynamics, as a component of research supported largely by the National Institutes of Health. The instrument will be housed in a new 2,000 sq-ft Biomolecular NMR Facility recently constructed by the Robert Wood Johnson Medical School (RWJMS) of the University of Medicine and Dentistry of New Jersey (UMDNJ), and will be used primarily by faculty and scientists from RWJMS and Rutgers University, including members of the Center for Advanced Biotechnology and Medicine, the Cancer Institute of New Jersey, Howard Hughes Medical Institute, the Center for Integrative Proteomics Technologies, and the DIMACS Institute for Quantitative Biology. In addition, the 800 MHz NMR instrument will be made available to researchers from Cornell University, Oklahoma State University, University of Nebraska, University of Kansas, University of Vermont, and from local New Jersey - based pharmaceutical and biotechnology companies. Finally, the instrumentation will be used to support research in high-throughput protein structure production by the NIH-funded Northeast Structural Genomics Consortium.