Acquisition of 800 MHz NMR System with Cryogenic Probe

描述（由申请人提供）：这是为了申请800 MHz核磁共振（NMR）系统的部分资金，该系统配有低温探针，用于生物分子和结构蛋白质组学研究。资金余额将由机构配套资金、工业礼品和已为此目的批准的其他赠款资金共同提供。带有低温探针的800 MHz NMR系统将主要用于蛋白质和核酸结构和动力学的研究，作为主要由美国国立卫生研究院支持的研究的一个组成部分。该仪器将安装在最近由新泽西医学和牙科大学（UMDNJ）的罗伯特·伍德约翰逊医学院（RWJMS）建造的新的2,000平方英尺生物分子NMR设施中，并将主要由RWJMS和罗格斯大学的教师和科学家使用，包括先进生物技术和医学中心，新泽西癌症研究所，霍华德休斯医学研究所、整合蛋白质组学技术中心和DIMACS定量生物学研究所。此外，800兆赫核磁共振仪器将提供给来自康奈尔大学、俄克拉荷马州州立大学、内布拉斯加大学、堪萨斯大学、佛蒙特大学以及当地新泽西制药和生物技术公司的研究人员。最后，仪器将用于支持由NIH资助的东北结构基因组学联盟进行的高通量蛋白质结构生产研究。

DESCRIPTION (provided by applicant): This is to request partial funding for an 800 MHz nuclear magnetic resonance (NMR) system, with cryogenic probe, for biomolecular and structural proteomics research. The balance of funding will be provided from a combination of institutional matching funds, industrial gifts, and other grant funds that have already been approved for this purpose. The 800 MHz NMR System with cryogenic probe will be used primarily for studies of protein and nucleic acid structure and dynamics, as a component of research supported largely by the National Institutes of Health. The instrument will be housed in a new 2,000 sq-ft Biomolecular NMR Facility recently constructed by the Robert Wood Johnson Medical School (RWJMS) of the University of Medicine and Dentistry of New Jersey (UMDNJ), and will be used primarily by faculty and scientists from RWJMS and Rutgers University, including members of the Center for Advanced Biotechnology and Medicine, the Cancer Institute of New Jersey, Howard Hughes Medical Institute, the Center for Integrative Proteomics Technologies, and the DIMACS Institute for Quantitative Biology. In addition, the 800 MHz NMR instrument will be made available to researchers from Cornell University, Oklahoma State University, University of Nebraska, University of Kansas, University of Vermont, and from local New Jersey - based pharmaceutical and biotechnology companies. Finally, the instrumentation will be used to support research in high-throughput protein structure production by the NIH-funded Northeast Structural Genomics Consortium.