Mechanism of Regulation of Intestinal Environment and Biological Functions by Food Components

食物成分调节肠道环境和生物功能的机制

• 批准号: 06660153
• 负责人: HAYAKAWA Takashi
• 金额: $ 1.28万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06660153/
• 关键词: resistant starch; intestinal environment; dietary fiber; fermentation; cholesterol; triglyceride; 生体機能調節; 難消化性澱粉; 短鎖脂肪酸; 盲腸

Indigestible starch component is present in starchy food. This may function to improve intestinal functions like dietary fiber. In this experiment, resistant starch (RS) was prepared from high-amylose starch and investigated its functions in comparison to dietary fiber such as pectin (PE) and konjac mannan (KM). Five-weeks-old rats of the Wistar strain were fed diets containing each DF source at levels of 4 and 8% as DF in diets for 3 weeks as cellulose powder as the control. RS was revealed to be fermentable like water soluble DFs (PE and KM) and contribute to the lowering of intestinal environment with production of short-chain fatty acids though it was classified as insoluble DF.In 8%RS group significant decrease in the levels of cholesterol and triglyceride in plasma was observed concomitant with decreases in liver lipids. Excretion of bile acids tended to be low in RS and KM,but was tended to be high in PE.Fecal cholestrol tended to be high in RS,KM and especially in PE.However fecal coprostanol was significantly lower in all test groups. Fecal neutral steroids tended to be low in 8%RS and 8%KM,and high in PE.The function of RS was not originated from inhibition of absorption like PE,but seemed to affect the host animal by suppressing biotransformation of primary substances to secondary substances through improvement of intestinal environment.

淀粉类食物中存在难消化的淀粉成分。这可能有助于改善膳食纤维等肠道功能。在本实验中，由高直链淀粉制备抗性淀粉（RS），并与果胶（PE）和魔芋甘露聚糖（KM）等膳食纤维进行比较，研究其功能。五周大的 Wistar 品系大鼠被喂食含有每种 DF 源的饮食，饮食中 DF 含量分别为 4% 和 8%，以纤维素粉末作为对照，持续 3 周。 RS被发现与水溶性DF（PE和KM）一样可发酵，尽管它被归类为不溶性DF，但它有助于降低肠道环境并产生短链脂肪酸。在8％RS组中，观察到血浆中胆固醇和甘油三酯水平显着降低，同时肝脏脂质降低。胆汁酸的排泄在RS和KM中趋于较低，而在PE中趋于较高。粪便胆固醇在RS、KM中尤其是在PE中趋于较高。而粪便粪前列醇在所有测试组中均显着较低。粪便中性类固醇在8%RS和8%KM中偏低，而在PE中偏高。RS的功能并不像PE那样源于抑制吸收，而是通过改善肠道环境，抑制初级物质向次级物质的生物转化来影响宿主动物。