Basic studies on positive imaging of hypoxic tissue in malignant tumor
恶性肿瘤缺氧组织阳性显像的基础研究
基本信息
- 批准号:06670911
- 负责人:
- 金额:$ 1.09万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1994
- 资助国家:日本
- 起止时间:1994 至 1995
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Malignant tumors mostly contain hypoxic tissue, which is registant to radiation therapy. We performed the basic studies on positive imaging using a radiotracer which accumulates to hypoxic cells. 1- (N- (4'-hydroxy-pheny1) acetamide-2-nitroimidazole, a new 2-nitroimidazole derivative including a phenol residue was labeled with I-125 or I-123 by the conventional chrolamine-T method. Higher cell accumulation of radioactivity was observed in relation to decreased oxygen concentrations. Tissue distribution study in tumor bearing mice showed significant retention of radioactovity in the tumors, while, normal aerobic tissues rapidly uptook and cleared parallel to blood clearance. Autoradiography imaged irregular distribution of radioactivity in the tumor, that was similar to that of C-14 labeled 2-deoxyglucose. After radiation therapy, tumor uptake was lower than that before therapy. MR spectroscopy also showed improved Pi/b-NTP ratio and pH values after radiation therapy, that suggested reoxygenation of tumor tissue. Our preliminary studies indicate that imaging with I-123 labeled nitroimidazole derivatives may be promise for positive detection of malignant tumors and potentially in predicting tumor response to radiation therapy and/or monitoring the therapeutic effect at the earlier phase.
恶性肿瘤大多含有乏氧组织,这对放射治疗是不敏感的。我们进行了基础研究,积极成像使用放射性示踪剂,积累到缺氧细胞。1-用铬胺-T法分别用I-125或I-123标记了一种新的含酚基的2-硝基咪唑衍生物(N-(4 '-羟基苯基)乙酰胺-2-硝基咪唑)。观察到与氧浓度降低相关的放射性细胞蓄积较高。荷瘤小鼠的组织分布研究显示,肿瘤中的放射性显著保留,而正常需氧组织快速吸收并清除,与血液清除平行。放射自显影显示肿瘤内放射性不规则分布,与C-14标记的2-脱氧葡萄糖相似。放射治疗后肿瘤摄取较治疗前降低。磁共振波谱也显示放射治疗后Pi/b-NTP比值和pH值的改善,这表明肿瘤组织的复氧。我们的初步研究表明,与I-123标记的硝基咪唑衍生物的成像可能是有希望的恶性肿瘤的阳性检测和潜在的预测肿瘤对放射治疗的反应和/或监测在早期阶段的治疗效果。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
YAMAMOTO Kazutaka其他文献
YAMAMOTO Kazutaka的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('YAMAMOTO Kazutaka', 18)}}的其他基金
High hydrostatic pressure inactivation of Escherichia coli under molecular crowding conditions
分子拥挤条件下高静水压灭活大肠杆菌
- 批准号:
20K05887 - 财政年份:2020
- 资助金额:
$ 1.09万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Study of three-dimensional positron emission tomography for wholebody evaluation of malignant tumor
三维正电子发射断层扫描对恶性肿瘤全身评估的研究
- 批准号:
08671013 - 财政年份:1996
- 资助金额:
$ 1.09万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
相似海外基金
Microspect Scanner for Small Animal Radionuclide Imaging
用于小动物放射性核素成像的显微扫描仪
- 批准号:
7795376 - 财政年份:2010
- 资助金额:
$ 1.09万 - 项目类别:
Radionuclide imaging for tissue characterization and treatment effect of experimental atherosclerosis
放射性核素成像用于实验性动脉粥样硬化的组织表征和治疗效果
- 批准号:
20390321 - 财政年份:2008
- 资助金额:
$ 1.09万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
High-resolution focusing optics for small animal radionuclide imaging
用于小动物放射性核素成像的高分辨率聚焦光学器件
- 批准号:
7127138 - 财政年份:2006
- 资助金额:
$ 1.09万 - 项目类别:
High-resolution focusing optics for small animal radionuclide imaging
用于小动物放射性核素成像的高分辨率聚焦光学器件
- 批准号:
7282739 - 财政年份:2006
- 资助金额:
$ 1.09万 - 项目类别:
Radionuclide imaging of apoptosis in irradiated tumors
辐射肿瘤细胞凋亡的放射性核素成像
- 批准号:
14570840 - 财政年份:2002
- 资助金额:
$ 1.09万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Radionuclide imaging and therapy dosimetry system
放射性核素成像和治疗剂量测定系统
- 批准号:
6335978 - 财政年份:2001
- 资助金额:
$ 1.09万 - 项目类别: