权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Study of three-dimensional positron emission tomography for wholebody evaluation of malignant tumor

三维正电子发射断层扫描对恶性肿瘤全身评估的研究

基本信息

批准号：
08671013
负责人：
YAMAMOTO Kazutaka
金额：
$ 1.02万
依托单位：
Fukui Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1997
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671013/
关键词：
three-dimensional PET F-18 FDG malignant tumor two-dimensional PET wholebody PET imaging F-18FDG

项目摘要

We undercarried basic and clinical studies of three-dimensional positron emission tomography (3D-PET) using F-18 labeled fluoro-2-deoxyglucose (FDG) for wholebody evaluation of malignant tumors. On the basis of research results in 1997, suitable examination method of 3D-PET was determined that injection dose of F-18 FDG was 111-185 MBq, data acquisition (2min each) was repeated 7-8 times moving the bed position. In comparison with conventional 2D-PET,injection dose was less than a half, and acquisition time was shortened about a half. We evaluated patients with lung cancer, prostatic cancer, head and neck tumors and so on. Malignant tumors were clearly visualized as hot lesions on 3D-PET wholebody images. 3D-PET using F-18 FDG was non-invasive and could detect metastatic lesions which were not found with previos examinations, therefore, it was concluded to be very useful for wholebody screening of malignant tumors. This 3D-PET examination using F-18 FDG will be applied to patients as a highly advanced medical treatment in Fukui Medical University Hospital. However, 3D-PET with F-18 FDG was not so suitable for the detection of metastatic lesions in the brain as MRI,since normal brain tissue also accumulated F-18 FDG.In basic study, quantitation of regional radioactivity could be correctly achieved on 3D-PET by the correction of scatter fraction from outside of acquisition field. Since the positron camera used in this study could not acquire transmission scan in 3D mode, attenuation and scatter correction for quantitative assessment could not be performed in patient studies. In order to obtain quantitative results in wholebody 3D-PET,positron camera capable to simultaneous emission and transmision data acquisition should be necessory.

我们开展了使用F-18标记的氟-2-脱氧葡萄糖（FDG）进行三维正电子发射断层扫描（3D-PET）用于恶性肿瘤全身评估的基础和临床研究。根据1997年的研究结果，确定了合适的3D-PET检查方法：F-18 FDG注射剂量为111-185 MBq，移动床位重复采集数据（每次2min）7-8次。与传统2D-PET相比，注射剂量减少一半以下，采集时间缩短一半左右。我们评估了肺癌、前列腺癌、头颈肿瘤等患者。恶性肿瘤在 3D-PET 全身图像上清晰可见为热病灶。使用F-18 FDG的3D-PET是非侵入性的，可以检测到以前检查中未发现的转移病灶，因此，它对于恶性肿瘤的全身筛查非常有用。这种使用F-18 FDG的3D-PET检查将作为福井医科大学医院的先进医疗应用于患者。然而，带有F-18 FDG的3D-PET并不像MRI那样适合检测脑部转移性病灶，因为正常脑组织也积累了F-18 FDG。在基础研究中，通过从采集场外部校正散射分数，可以在3D-PET上正确实现区域放射性的定量。由于本研究中使用的正电子相机无法以3D模式获取透射扫描，因此无法在患者研究中进行用于定量评估的衰减和散射校正。为了获得全身3D-PET的定量结果，需要能够同时采集发射和传输数据的正电子相机。