Radiological and anatomical study on the development of the cavernous sinus and its draining veins in human fetuses.

人类胎儿海绵窦及其引流静脉发育的放射学和解剖学研究。

• 批准号: 06671430
• 负责人: HASHIMOTO Masanori
• 金额: $ 1.15万
• 依托单位: University of Occupational and Environmental Health
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671430/
• 关键词: cavernous sinus; fetus; development; 顕微鏡下解剖; 静脈造影

Development of the cavernous sinus and its draining venous system was investigated in the aborted fetuses ranging from 3 to 7 months of gestational age. Stereoroentogenography was taken multi-directionally for fetuses in whom contract material had been injected into the venous system. Serial sections of the skull base around the cavernous sinus were prepared for histological staining in fetuses without contrast injection. Results of radiological and anatomical observations are summarized as follows ;1) The cavernous sinus is formed initially as a sparse venous channels around the internal carotid artery in the beginning of fetal stage (about 3 months of gestational age).2) At the stage of 4 and 5 months, plexiform venous channels develop in the cavernous sinus to connect extracranially with the orbital veins and intracranially with the inferior petrosal sinus. The inter-cavernous sinus appears as a connecting channel of the bilateral cavernous sinuses, and the middle cerebral vein begins to drain into the cavernous sinus at this stage. Microscopicaly, the venous channels in the cavernous sinus increase in number and size at this stage, and are formed between two leaves of the dura mata.3) After 6 months of gestational age, plexiform venous channels converge into the several large veins, and the adult type of cavernous sinus is formed to connect between the orbital and the intracranial veins.

对3~7月龄流产胎儿的海绵窦及其引流静脉系统的发育进行了观察。对静脉系统内注入对比物的胎儿进行多方位立体定位造影术。在未注射造影剂的情况下，取胎儿颅底海绵窦周围的连续切片进行组织学染色。结果如下：1)海绵窦最初形成于胎儿期(约3个月)颈内动脉周围稀疏的静脉通道；2)4个月和5个月时，海绵窦内发育丛状静脉通道，与眶外静脉相连，与岩下窦内相连。海绵间窦是双侧海绵窦的连接通道，大脑中静脉在此阶段开始向海绵窦内引流。3)胎龄6个月后，丛状静脉通道汇合成数条大静脉，形成连接眶静脉和颅内静脉的成人型海绵窦。