Development of self healing materials with remineralization(Bioglass for dental materials)

开发再矿化自愈材料（牙科材料用生物玻璃）

• 批准号: 18592226
• 负责人: HASHIMOTO Masanori
• 金额: $ 2.35万
• 依托单位: Health Sciences University of Hokkaido (2007)Hokkaido University (2006)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18592226/
• 关键词: Self-healing; remineralization; bioglass; restorative dentistry; adhesive interface; microleakage; resin adhesive; glass-ionomer; 石灰化; 象牙質; エナメル質; 走査型電子顕微鏡; 透過型電子顕微鏡

A finding in this study was that crystal formation (approximately 10 μm in diameter) was a common feature of some fluoridated adhesive resins, where were separated by a standardized interfacial gap between teeth and cured materials. This crystal growth was also found in bioglass (Na_2-CaO-SiO_2-P_2O_5) -containing adhesive resins after several months of water storage. The mechanical properties of resin adhesives are completely reduced by bioglass addition. The decreasing amount of bioglass addition for adhesives prevents a reduction of mechanical property of materials but it reduces an amount of ion releasing for remineralization. The reduction of mechanical property may induced by crystal growth formation due to simultaneous response between bioglass and water. In theory, there are one possibility for increasing the surface area of bioglass per unit, and thus making them more active. An future approach may be simply to decrease glass particle size (nano-sized bioglass), and thus increase the ion exchange surface of glass and surrounding liquid, and prevent mechanical property decreasing for clinical use.

本研究的一个发现是，晶体形成（直径约10 μm）是某些氟化粘合树脂的共同特征，这些树脂被牙齿和固化材料之间的标准化界面间隙隔开。在含Na_2-CaO-SiO_2-P_2O_5的胶粘剂树脂中，经几个月的水贮存后，也发现了这种晶体生长。树脂胶粘剂的机械性能完全降低了玻璃的加入。用于粘合剂的玻璃纤维添加量的减少防止了材料的机械性能的降低，但它减少了用于再矿化的离子释放量。由于玻璃与水的同时反应，形成晶体生长，导致力学性能下降。从理论上讲，有一种可能性是增加每单位玻璃的表面积，从而使它们更活跃。未来的方法可能是简单地减小玻璃颗粒尺寸（纳米尺寸的玻璃），从而增加玻璃和周围液体的离子交换表面，并防止机械性能降低以用于临床使用。

项目成果

グラスアイオノマーセメントのフッ素リチャージ時におけるフッ素浸透度について

玻璃离子水门汀补氟过程中的氟渗透率

• 发表时间: 2007
• 作者: 中村 光一;ら
• 通讯作者: ら

The extent of fluoride releasing and infiltration from glass-ionomer cement after recharging

充填后玻璃离子水门汀中氟的释放和渗透程度

• 发表时间: 2007

Crystal growth by fluoridated adhesive resins

• DOI: 10.1016/j.dental.2007.04.014
• 发表时间: 2008-04-01
• 期刊: DENTAL MATERIALS
• 影响因子: 5
• 作者: Hashimoto, Masanori;Nakamura, Kouichi;Yawaka, Yasutaka
• 通讯作者: Yawaka, Yasutaka