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Studies on Polymer Structures and Functions in Nanometric Dimensions: Challenges to Ten Nano-meters Regions by Scanning Photon Microscopy

纳米尺寸聚合物结构与功能研究：扫描光子显微镜挑战十纳米区域

基本信息

批准号：
15205016
负责人：
ITO Shinzaburo
金额：
$ 32.86万
依托单位：
KYOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

This research project is aimed at development of a novel scanning photon microscope characterized both with high spatial resolutions of 10-100 nm and with high sensitivities capable of detecting extremely weak emission from a single molecule. Owing to the excellent performance, this research could exemplify the usefulness of this novel method for studying polymer structures and functions in the "critical dimensions" between microscopic molecular systems and macroscopic bulk systems. The issues investigated during the project term are listed as follows;1. Real space imaging of conformation and expansions of single polymer chains in a polymer matrix2. Polymer structure and entanglement in a restricted space such as ultra-thin polymer films and surfaces3. Quantitative evaluation of spatial distribution of near-field optical waves and spatial resolution of microscope by using model samples prepared with highly fluorescent quantum dots4. Analysis of molecular diffusion at the polymer surface and interfaces in a nanometric dimensions5. Study of segmental orientation of main-chain conjugated polymers by fluorescence polarization imaging with a dual detection scanning photon microscope6. Polymer chain orientation under mechanical elongation of polymer films; comparative study of macroscopic stress-strain and molecular level orientation7. Development of a new scanning photon microscope working for a liquid environment specimen, and high resolution observation of biomaterials.

该研究项目旨在开发一种新型扫描光子显微镜，其特点是具有10-100 nm的高空间分辨率和高灵敏度，能够检测单个分子的极微弱发射。由于其优异的性能，本研究可以证明这种新方法在研究介于微观分子体系和宏观体相体系之间的“临界尺寸”的聚合物结构和功能方面的有用性。项目期间调查的问题如下：1.聚合物基质中单个聚合物链的构象和膨胀的真实的空间成像2.聚合物结构和缠结在一个有限的空间，如超薄聚合物薄膜和表面3。用高荧光量子点制备的模型样品定量评价近场光波的空间分布和显微镜的空间分辨率4.纳米尺度下聚合物表面和界面的分子扩散分析5.双探测扫描光子显微镜荧光偏振成像研究主链共轭聚合物链段取向6。高分子薄膜机械拉伸下的高分子链取向;宏观应力-应变与分子水平取向的比较研究7.研制新型液体环境样品扫描光子显微镜，并对生物材料进行高分辨率观察。