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Molecular Epidemiological Study of Thyroid Disease in Radiation Contaminated Area

辐射污染地区甲状腺疾病的分子流行病学研究

基本信息

批准号：
15256004
负责人：
NAMBA Hiroyuki
金额：
$ 22.38万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

In this study, our group is participating in International Chernobyl Tissue Bank Project, which stocks and manages nuclear acids extracted from Chernobyl childhood thyroid cancer tissues for research purpose. We collaborate international medical care with Medical Radiological Research Centre, Russian Academy of Medical Sciences (Russian Federation), Belarusian Medical University (Republic of Belarus), Research Center for Radiation Medicine of the Academy of Medical Sciences of Ukraine (Ukraine) and Research Institute for Radiation Medicine and Ecology (Republic of Kazakhstan). We accepted and trained 18 research scientists from these collaboration Universities and Institutes in our institute during last three years. We established telemedicine and teleeducation system between Gomel Medical University (Republic of Belarus) and our institute to give lectures to medical students in Gomel Medical University. Our group also visited Gomel and Minsk for three weeks every year to take the helm on molecular epidemiological study and e-Learning system. We analyzed mitochondria DNA and genomic DNA extracted from Chernobyl childhood thyroid cancer tissues to find radiation signatures left in the DNA. As the results, we found large deletion of mitochondria DNA and unique SNPs sites in DNA repair related genes including TP53, ATM and MDM2 genes in radiation associated thyroid cancers. Through this study, we found new findings of radiation associated thyroid cancer and promoted international exchanges regarding scientific research and educations. We hope further extending studies in this field.

在这项研究中，我们的小组正在参与国际切尔诺贝利组织库项目，该项目储存和管理从切尔诺贝利儿童甲状腺癌组织中提取的核酸用于研究目的。我们与医学放射研究中心，俄罗斯医学科学院（俄罗斯联邦），白俄罗斯医科大学（白俄罗斯共和国），乌克兰医学科学院放射医学研究中心（乌克兰）和放射医学和生态研究所（哈萨克斯坦共和国）合作开展国际医疗服务。在过去的三年里，我们接受并培训了来自这些合作大学和研究所的18名研究科学家。我们在戈梅利医科大学（白俄罗斯共和国）和我们的研究所之间建立了远程医疗和远程教育系统，为戈梅利医科大学的医学生提供讲座。我们的团队还每年访问戈梅利和明斯克三周，负责分子流行病学研究和电子学习系统。我们分析了从切尔诺贝利儿童甲状腺癌组织中提取的线粒体DNA和基因组DNA，以寻找DNA中留下的辐射特征。结果发现，在放射相关甲状腺癌中存在线粒体DNA的大量缺失和DNA修复相关基因TP53、ATM和MDM2的独特SNPs位点。通过本研究，我们发现了辐射相关甲状腺癌的新发现，促进了国际科研和教育交流。我们希望在这一领域的研究能进一步扩大。