Comprehensive Study of Carcinogemesis and Molecular Target Therapy in Thyroid Cancer

切尔诺贝利核电站事故已经过去20年了。事故发生5年后，生活在受污染地区的儿童甲状腺癌发病率有所上升。甲状腺癌的数量仍在增加。根据原子能机构和世卫组织2005年9月在维也纳共同主办的切尔诺贝利论坛的资料，儿童甲状腺癌的总人数为4000例，其中9例死亡。本病预后较好，但似乎有20%的患者会复发或转移到肺、骨等远处器官。对于常规治疗方法难以治疗的疾病，有必要开发新的治疗药物。在这项研究中，我们进行了一项研究，开发了一种新的诊断方法，通过微阵列分析来区分恶性肿瘤，良性肿瘤容易转移到远处器官。我们进一步开展了分子靶点药物如c-ABL抑制剂Glivec和NF-kB抑制剂DHMEQ对间变性甲状腺癌的基础研究。我们报道了这些药物在体外和体内实验中对甲状腺间变性癌都有显著的疗效。为了提高治疗效果，我们现在正在研究癌症干细胞，它似乎是甲状腺癌癌症治疗的真正目标。我们希望继续在这一领域的转化研究，直到建立良好的诊断和治疗工具。

It has been passed 20 years after Chernobyl nuclear power plant accident. Incidence of thyroid cancer was increased in children living contaminated area 5 years after the accident. The number of thyroid cancer still increase. According the information of Chernobyl Forum co-hosted IAEA and WHO in Vienna September 2005, total number of childhood thyroid cancer is 4,000 cases and 9 cases died among them. The disease is relatively good prognosis, however, it seemed that 20% of patients will have recurrence or metastasis to distant organs such as lung and bone. It is necessary to develop the new therapeutic remedy for the disease that is difficult for treat by conventional therapies. In this study, we performed studies to develop a new diagnostic method that discriminates malignant tumors benign that is prone to metastasize to distant organs by microarray analysis. We, further, carried on the basic studies for molecular target drugs such as Glivec, a c-ABL inhibitor, and DHMEQ, a NF-kB inhibitor to anaplastic thyroid cancer. We reported that these drugs were significantly efficient anaplastic thyroid cancers both in vitro and in vivo experiments. To enhance the therapeutic effect, we are, now, investigating cancer stem cells that seem to be real target of cancer therapy in thyroid cancer. We hope to continue to translational research in this field until establishment of good diagnostic and therapeutic tools.