Cryo-Transmission Electron Microscope 200 kV

研究的目的是了解动态蛋白质组装和机器，利用ATP的能量来控制复杂的细胞过程。综合结构生物学通过可视化不同构象的分子机器，在我们的研究方法中起着重要作用。目前的研究项目和未来的活动需要一台200kV的筛选低温透射电子显微镜。由于这种类型的高端显微镜有限，法兰克福歌德大学迫切需要冷冻透射电镜。该仪器补充了已有10年历史的Krios I，拥有62.5%的Uni份额，主要用于电子断层扫描。Cryo-TEM是一种在分辨率、高效样品分析和通用用户友好性方面满足最高要求的设备。相应的cryo-EM基础设施在现场可用，这确保了即时和快速的调试，也保证了参与应用过程的工作组有效使用和广泛的用户。

Research aims at understanding dynamic protein assemblies and machineries that use the energy of ATP to control complex cellular processes. Integrated structural biology plays an important role in our research approaches by visualizing molecular machines in different conformations. A screening cryo transmission electron microscope (TEM) 200kV is requested for current research projects and future activities. Due to the limited access to high-end microscope of this type, there is an urgent need for a cryo-TEM at the Goethe University Frankfurt. The instrument complements the ten-year-old Krios I with a 62.5% Uni share, which is mainly used for electron tomography. The Cryo-TEM is a device that meets the highest requirements in terms of resolution, efficient sample analysis, and universal user-friendliness. A corresponding cryo-EM infrastructure is available at the location, which ensures immediate and quick commissioning and also guarantees the working groups involved in the application process an efficient use and a wide range of users.