Cryo Transmission Electron Microscope for SPA, Cryo-ET and MicroED studies at UCSB

UCSB 用于 SPA、Cryo-ET 和 MicroED 研究的冷冻透射电子显微镜

基本信息

  • 批准号:
    10177740
  • 负责人:
  • 金额:
    $ 200万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-07-01 至 2024-06-30
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT With the purchase of a GlaciosTM transmission electron microscope system we seek to establish the first single particle analysis (SPA) cryo-electron microscopy (cryo-EM), -electron tomography (-ET) and micro-electron diffraction (micro- ED) facility at the University of California Santa Barbara, and the only one on the California Central Coast: the UCSB Structural Biology cryo-Electron Microscopy (SB2EM) facility. Dedicated biological cryo-EM capabilities will become the linchpin to UCSB’s strong leadership and strength in quantitative biology, structural biochemistry and bioengineering at the interdisciplinary interface. Nowhere is the boundary between Departments, Colleges and Programs more permeable than at UCSB: faculty advise PhD students of all Science and Engineering Departments with no to little barriers, dual appointments in more than one department is the norm at UCSB and research operations relying on high-end and state-of-the-art instrumentation in professionally run shared facilities is a forte of the UCSB campus. The SB2EM facility will be integrated into this culture of interdisciplinary collaboration, as well as a network of first-rate shared facilities and laboratories across our campus’s largely merged science and engineering community. The impact of SB2EM on the current NIH funded UCSB faculty will be direct, immediate and dramatic, but it will also go well beyond the currently funded NIH projects by inspiring and enabling entirely new areas of biomedically inspired research, and the hiring of new faculty talent. The ability to the “turn the lights on” to directly see the molecular machinery of life fundamentally changes how we understand and, ultimately, manipulate biological materials, systems and processes. Cryo-EM brings atomic- and molecular- level information, typically the core approach of a chemist, into biology and bioengineering, and vice versa, through, for example, the visualization of how molecular chaperones untangle neurofibrillary plaques, or through the structure-based engineering of molecular inhibitors and architectures built of protein and nucleic acid building blocks. The emergence of unprecedentedly high-resolution structural insights into biological molecules and systems offers a critical competitive advantage towards understanding their functions, discovering function-driving mechanisms, and engineering therapeutic solutions. The study of the protein function will be dramatically facilitated and the re-engineering of biological systems vastly enhanced with knowledge of the underlying structure and structural characteristics. It is this insight that led us to prioritize structure-based biochemistry, bioorganic chemistry, biology, and bioengineering at UCSB.
项目总结/文摘

项目成果

期刊论文数量(0)
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DORIT HANEIN其他文献

DORIT HANEIN的其他文献

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{{ truncateString('DORIT HANEIN', 18)}}的其他基金

Structure and function of the Plasmodium myosin XIV-actin glideosome
疟原虫肌球蛋白 XIV 肌动蛋白滑胶体的结构和功能
  • 批准号:
    9363011
  • 财政年份:
    2017
  • 资助金额:
    $ 200万
  • 项目类别:
Structure and function of the Plasmodium myosin XIV-actin glideosome
疟原虫肌球蛋白 XIV 肌动蛋白滑胶体的结构和功能
  • 批准号:
    9913454
  • 财政年份:
    2017
  • 资助金额:
    $ 200万
  • 项目类别:
Molecular mechanism of BCL2-dependent apoptosis
BCL2依赖性细胞凋亡的分子机制
  • 批准号:
    8856525
  • 财政年份:
    2014
  • 资助金额:
    $ 200万
  • 项目类别:
International Conference on Image Analysis in Three-dimensional Cryo-EM
三维冷冻电镜图像分析国际会议
  • 批准号:
    8785968
  • 财政年份:
    2014
  • 资助金额:
    $ 200万
  • 项目类别:
Molecular mechanism of BCL2-dependent apoptosis
BCL2依赖性细胞凋亡的分子机制
  • 批准号:
    8702959
  • 财政年份:
    2014
  • 资助金额:
    $ 200万
  • 项目类别:
Instrumentation Upgrade: acquisition of an intermediate voltage TEM
仪器升级:获取中间电压 TEM
  • 批准号:
    8335214
  • 财政年份:
    2012
  • 资助金额:
    $ 200万
  • 项目类别:
Core A: ADMINISTRATIVE
核心A:行政
  • 批准号:
    8234231
  • 财政年份:
    2011
  • 资助金额:
    $ 200万
  • 项目类别:
Ultrastructural Basis of Mechanotransduction in Matrix Adhesions
基质粘附力传导的超微结构基础
  • 批准号:
    8550088
  • 财政年份:
    2011
  • 资助金额:
    $ 200万
  • 项目类别:
Ultrastructural Basis of Mechanotransduction in Matrix Adhesions
基质粘附力传导的超微结构基础
  • 批准号:
    8165563
  • 财政年份:
    2011
  • 资助金额:
    $ 200万
  • 项目类别:
Ultrastructural Basis of Mechanotransduction in Matrix Adhesions
基质粘附力传导的超微结构基础
  • 批准号:
    8333958
  • 财政年份:
    2011
  • 资助金额:
    $ 200万
  • 项目类别:

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