Promotion of cardiovascular physiome focusing on coronary microcirculation and myocardial crossbridge dynamics
Promotion of cardiovascular physiome focusing on coronary microcirculation and myocardial crossbridge dynamics
批准号:
17200033
负责人:
KAJIYA Fumihiko
金额:
$30.04万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2008
中文摘要
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英文摘要
心臓が統合的に機能を発揮するためには、アクチン・ミオシン(AM)架橋の形成と解離と冠微小循環の動態が正常に機能する必要がある。そこで、AM挙動はSPring-8放射光を用いて摘出灌流心(ラット)のX線回折像によって解析し、心筋微小循環は高倍率/高速CCDビデオ顕微鏡で可視化観測した。その結果、AM架橋と微小血管の相互作用が心機能と流れの維持にとって重要であることが示された。これらの結果をフィジオミックに評価するため心筋と冠血管のクロストークを考慮した冠循環のモデルを作成し、モデル論的解析を行った。
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Adipose Tissue Remodeling and Malfunctioning in Obesity Revealed by in vivo Molecular Imaging
体内分子成像揭示肥胖症中的脂肪组织重塑和功能障碍
DOI:
--
发表时间:
2007
期刊:
Bioimages 15
影响因子:
--
作者:
[Nishimura S, Manabe I, Nagasaki M, Hosoya Y, Kadowaki T, Nagai R, Sugiura S]
通讯作者:
Sugiura S
Important role of endogenous hydrogen peroxide in pacing-induced metabolic coronary vasodilation in dogs in vivo
内源性过氧化氢在狗体内起搏诱导的代谢性冠状动脉舒张中的重要作用
DOI:
--
发表时间:
2007
期刊:
J Am Coll Cardiol. 50(13)
影响因子:
--
作者:
[Yada T, Shimokawa H, Hiramatsu O, Shinozaki Y, Mori H, Goto M, Ogasawara Y, Kajiya F]
通讯作者:
Kajiya F
Impaired coronary capillary flow with decreased glycocalyx thickness and irregular inner wall in right ventricle of pulmonary hypertensive rats
肺动脉高压大鼠冠状毛细血管血流受损、糖萼厚度减少、右心室内壁不规则
DOI:
--
发表时间:
2006
期刊:
影响因子:
--
作者:
[T. Tosaka, et. al., Kajiya M.]
通讯作者:
Kajiya M.
Direct measurement of nitric oxide during experimental cardiopulmonary bypass.
实验性体外循环过程中直接测量一氧化氮。
DOI:
--
发表时间:
2005
期刊:
J Int Med Res. 33・3
影响因子:
--
作者:
[Hamanaka S, Tanemoto K Inagaki E, Yamasawa T, Yoshida K, Mochizuki S, Goto M, Miyasaka T, Kajiya F, Tanaka N.]
通讯作者:
Tanaka N.
Digital radiographic quantification of myocardial blood flow around a transmyocardial laser channel in rabbit hearts.
兔心脏跨心肌激光通道周围心肌血流的数字射线照相定量。
DOI:
--
发表时间:
2005
期刊:
Circ J. 69・4
影响因子:
--
作者:
[Honjo O, Ishino K, Matsumoto T, Yamamoto S, Asai T, Kohmoto T, Kajiya F, Sano S.]
通讯作者:
Sano S.
共 66 条
Analysis of coronary microcirculation and myocardial crossbridge dynamic using SPring-8 synchrotron facility
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批准号:13854030
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$58.24万
-
财政年份:2001
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负责人:KAJIYA Fumihiko
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依托单位:
Micromechanics Control of Coronary Circulation
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批准号:10044330
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项目类别:Grant-in-Aid for Scientific Research (A).
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资助金额:$6.98万
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财政年份:1998
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负责人:KAJIYA Fumihiko
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依托单位:
Analysis on myocardial ischemia by observation of NADH fluorescence/oxygen partial pressure phosphorescence using an intra-vital needle microscope
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批准号:10558140
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.94万
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财政年份:1998
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负责人:KAJIYA Fumihiko
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依托单位:
Evaluation of time sequential changes in subendocardial arteioles in the hypertensive hypertrophic canine heart by using needle-lens CCD intravital microscope
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批准号:09480259
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.46万
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财政年份:1997
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负责人:KAJIYA Fumihiko
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依托单位:
Interaction of coronary hemodynamical and biomolecular signals
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批准号:08044329
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$9.86万
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财政年份:1996
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负责人:KAJIYA Fumihiko
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依托单位:
Evaluation of Subendocardial Microcirculatory Hemodynamics by High-Speed Needle-Probe CCD Microscope
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批准号:08558103
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$7.87万
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财政年份:1996
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负责人:KAJIYA Fumihiko
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依托单位:
Studies on Subendocardial Vulnerability to Underperfusion using a Needle-probe CCD microscope
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批准号:07670823
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.47万
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财政年份:1995
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负责人:KAJIYA Fumihiko
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依托单位:
A High Resolution CCD Intravital Fluorescent Microscope for Observation of Coronary Smaller Microvessels in a Beating Heart
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批准号:05557043
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$10.88万
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财政年份:1993
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负责人:KAJIYA Fumihiko
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依托单位:
Analysis of Coronary Slosh Phenomenon by Needle-probe CCD Microscope and Molecular Blood Flow Tracer
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批准号:05454278
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.35万
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财政年份:1993
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负责人:KAJIYA Fumihiko
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依托单位:
Analysis of coronary slosh phenomenon under coronary stenosis by measurement of blood flow or vasucular diameter in intramyocardial vessels and microvessels
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批准号:03454259
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.1万
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财政年份:1991
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负责人:KAJIYA Fumihiko
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依托单位:
Basic and Clinical Analysis of Macroscopic and Microscopic Characteristics of Coronary Circulation in Cardiac Hypertrophy
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批准号:01480253
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.42万
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财政年份:1989
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负责人:KAJIYA Fumihiko
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依托单位:
海外基金