Oxygen transfer tomography fix regulating the cerebral function and its application to the cerebral vascular diseasa

氧传输断层扫描对脑功能的调节及其在脑血管疾病中的应用

基本信息

批准号：
17206020
负责人：
TANISHITA Kazuo
金额：
$ 31.37万
依托单位：
Keio University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17206020/
关键词：
Cerebral function Oxygen transfer CT imaging Medical engineering Cerebral vessel Cerebral aneurysm Vascular surgery Stent トモグラフィ脳血流

项目摘要

We carried out the measurement of oxygen partial pressure in the guinea pig primary auditory cortex to evaluate the oxygen transfer in the cerebral tissue. Evoked neural activity and cortical tonotopic organization were measured with a voltage sensitive dye technique, whereas the cerebral blood flow response to neural stimulation was measured with laser-Doppler flowmetry. The VSD imaging showed that the sound induced activation area was dynamically varied. The CBF measurement clearly showed a less spatial specificity to the local neural activity determined with VSD. The findings indicate that a spatial coupling between neural activity measured with VSD and vascular response measured with LDF is dissociated in primary auditory eaten, which can be interpreted as indicating that the neurovascular response in the auditory system has variable sensitivities to globally induced subthreshold activity and/or unique regulatory mechanisms for spatial distribution of CBF.The neurovascular disease such as cerebral aneurysm occurred in bifurcation of the relatively large cerebral artery and we carried out the biomechanical consideration of cerebral aneurysm for the clinical diagnosis and treatment of cerebral aneurysm. Firstly we investigated the blood flow structure in the aneurysm for determining the risk factor of rupture. We proposed the hemodynamic hypothesis of risk factor for cerebral aneurysm where the intra-aneurysm flow should be responsible for the rupture. We carefully analyzed the flow in the artery model constructed based on the CT data of patient We showed some correlation between the rupture and intra aneurysm flow. To validate the hemodynamic hypothesis we perfumed the induced aneurysm model in the rat and rabbit In the induced aneurysm modes, we found out that the wall shear stress tends to be lower in the region of aneurysm and hemodynamic hypothesis may give some insight to the diagnosis and teamed of cerebral aneurysm.

我们在豚鼠原发性听觉皮层中测量了氧部分压力，以评估脑组织中的氧转移。用电压敏感的染料技术测量了诱发的神经活性和皮质调节组织，而用激光多普勒流量指定测量了对神经刺激的大脑血流反应。 VSD成像表明，声音诱导的激活区域动态变化。 CBF测量清楚地表明，对用VSD确定的局部神经活动的空间特异性较小。研究结果表明，用VSD测量的神经活动与用LDF测量的血管反应之间的空间耦合分离在原发性听觉中，这可以解释为表明听觉系统中的神经血管反应具有可变的敏感性，可与全球诱导的subthres subthres Action和/或独特的调节性机制相关。动脉瘤发生在相对较大的脑动脉的分叉中，我们对脑动脉瘤进行了生物力学考虑，用于临床诊断和治疗脑动脉瘤。首先，我们研究了动脉瘤中的血流结构，以确定破裂的危险因素。我们提出了脑动脉瘤的危险因素的血液动力学假设，其中 - 干扰素流动应导致破裂。我们仔细地分析了基于患者的CT数据构建的动脉模型中的流动，我们显示了破裂与动脉瘤内流量之间的某些相关性。为了验证血液动力学假设，我们在诱导的动脉瘤模式中为大鼠和兔子中诱导的动脉瘤模型灌输，我们发现在动脉瘤和血液动力学假设的区域中，壁剪应力往往较低，可能会使诊断和组合脑动力学的诊断和组合。