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Oxygen transfer tomography fix regulating the cerebral function and its application to the cerebral vascular diseasa

氧传输断层扫描对脑功能的调节及其在脑血管疾病中的应用

基本信息

批准号：
17206020
负责人：
TANISHITA Kazuo
金额：
$ 31.37万
依托单位：
Keio University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17206020/
关键词：
Cerebral function Oxygen transfer CT imaging Medical engineering Cerebral vessel Cerebral aneurysm Vascular surgery Stent トモグラフィ脳血流

项目摘要

We carried out the measurement of oxygen partial pressure in the guinea pig primary auditory cortex to evaluate the oxygen transfer in the cerebral tissue. Evoked neural activity and cortical tonotopic organization were measured with a voltage sensitive dye technique, whereas the cerebral blood flow response to neural stimulation was measured with laser-Doppler flowmetry. The VSD imaging showed that the sound induced activation area was dynamically varied. The CBF measurement clearly showed a less spatial specificity to the local neural activity determined with VSD. The findings indicate that a spatial coupling between neural activity measured with VSD and vascular response measured with LDF is dissociated in primary auditory eaten, which can be interpreted as indicating that the neurovascular response in the auditory system has variable sensitivities to globally induced subthreshold activity and/or unique regulatory mechanisms for spatial distribution of CBF.The neurovascular disease such as cerebral aneurysm occurred in bifurcation of the relatively large cerebral artery and we carried out the biomechanical consideration of cerebral aneurysm for the clinical diagnosis and treatment of cerebral aneurysm. Firstly we investigated the blood flow structure in the aneurysm for determining the risk factor of rupture. We proposed the hemodynamic hypothesis of risk factor for cerebral aneurysm where the intra-aneurysm flow should be responsible for the rupture. We carefully analyzed the flow in the artery model constructed based on the CT data of patient We showed some correlation between the rupture and intra aneurysm flow. To validate the hemodynamic hypothesis we perfumed the induced aneurysm model in the rat and rabbit In the induced aneurysm modes, we found out that the wall shear stress tends to be lower in the region of aneurysm and hemodynamic hypothesis may give some insight to the diagnosis and teamed of cerebral aneurysm.

我们对豚鼠初级听觉皮层的氧分压进行了测量，以评估脑组织中的氧传输。使用电压敏感染料技术测量诱发神经活动和皮质音位组织，而使用激光多普勒血流计测量对神经刺激的脑血流反应。 VSD 成像显示声音诱发的激活区域是动态变化的。 CBF 测量清楚地表明，用 VSD 确定的局部神经活动的空间特异性较低。研究结果表明，用 VSD 测量的神经活动和用 LDF 测量的血管反应之间的空间耦合在初级听觉中是分离的，这可以解释为表明听觉系统中的神经血管反应对全局诱导的阈下活动和/或 CBF 空间分布的独特调节机制具有可变的敏感性。脑动脉瘤发生在较大的脑动脉分叉处，我们针对脑动脉瘤的临床诊治开展了脑动脉瘤的生物力学考虑。首先，我们研究了动脉瘤内的血流结构，以确定破裂的危险因素。我们提出了脑动脉瘤危险因素的血流动力学假说，其中动脉瘤内血流应该是造成破裂的原因。我们仔细分析了根据患者 CT 数据构建的动脉模型中的血流，我们发现破裂与动脉瘤内血流之间存在一定的相关性。为了验证血流动力学假说，我们在大鼠和兔子中建立了诱导动脉瘤模型。在诱导动脉瘤模型中，我们发现动脉瘤区域的壁剪切应力往往较低，血流动力学假说可能为脑动脉瘤的诊断和治疗提供一些见解。