Connectiveness between micro and macroscopic biological flows

微观和宏观生物流之间的连通性

• 批准号: 09044180
• 负责人: TANISHITA Kazuo
• 金额: $ 8.51万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09044180/
• 关键词: biofluid mechanism; cellular mechanics; microscopic flow; biomechanics; respiration mechanics; arterial blood flow; mass tranfer; 動脈; 気道; 内皮細胞; 上皮細胞; 力学適応

The specific macroscopic function is achieved by integrating the microscopic phenomena in the biological system. In other words, the biological system will achieve the function by adopting the various environmental effects. In this project, we had been exploiting how the biological flow achieve the function in the living body, furthermore we took into account the solid mechanics, physiology, cell biology in addition to the fluid mechanics. The researchers in the international group got tother to tackle this problem and discuss various aspects of the biological flow phenomena being directly related to the function in the biological system. We had the meeting at Sapporo on last August, in 1998 to discuss several subjects of biological flow. The subjects we discussed were respiratory mechanics, cardiovascular fluid mechanics, cellular mechanics and transport phenomena. We also emphasized the function of endothelial cells under the mechanical stimulus and tried to understand the mechanotransduction mechanism of endothelial cells. The biological system is constructed by integrating the various level of biological units and we should understand the biological function through the integration of biological phenomena in the various levels. The integration becomes more important recently and shoud offer the new way of understanding thr biological system in the future.

特定的宏观功能是通过整合生物系统中的微观现象来实现的。换句话说，生物系统将通过采用各种环境效应来实现这一功能。在这个项目中，我们一直在探索生物流是如何在活体中实现功能的，除了流体力学之外，我们还考虑了固体力学、生理学、细胞生物学。国际小组的研究人员进一步解决了这个问题，并讨论了生物流动现象的各个方面，这些现象与生物系统中的功能直接相关。我们于去年8月在札幌举行了会议，讨论了生物流动的几个主题。我们讨论的主题是呼吸力学、心血管流体力学、细胞力学和运输现象。我们还强调了内皮细胞在机械刺激下的功能，并试图了解内皮细胞的机械转导机制。生物系统是通过整合不同层次的生物单位来构建的，我们应该通过整合各个层面的生物现象来理解生物的功能。这种集成在最近变得更加重要，并将为未来理解生物系统提供新的途径。

项目成果

Kamm, R. D.: "Pulmonary Flusd Mechanics"Third World Congress pf Biomechanics. 4 (1998)

Kamm, R. D.：“肺流感力学”第三届世界生物力学大会。

Tanishita, K. et al.: "Effect of wall shear stress on macromolecule uptake into cultured endotelial cells"Trans. JSME. Vol.64. 367-384 (1998)

Tanishita, K. 等人：“壁剪切应力对培养内皮细胞摄取大分子的影响”Trans。

Schroter,R.C.: "A model of lung alveolar mechanics" Third World Congress of Biomechanis. 70 (1998)

Schroter,R.C.：“肺泡力学模型”第三届世界生物力学大会。

Tanishita, et al.: "Angmentation of axial dispersion by intermittent oscillatory flow"Trans. ASEM, J. of Biomech. Eng. 120. 405-415 (1998)

Tanishita 等人：“间歇振荡流对轴向分散的控制”Trans。

Redley,T.J.: "Alteration of Mean Wall.Shear Stress neas on Oscillating Stagnation Point" Trans.ASME,J.of Biomech.Eng.120. 227-237 (1998)

Redley,T.J.：“平均壁的改变。振荡驻点上的剪切应力”Trans.ASME，J.of Biomech.Eng.120。