权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Enhancement of gas transfer due to the convective resonance in the bifurcating tube of the airway

由于气道分叉管中的对流共振而增强气体传输

基本信息

批准号：
10450077
负责人：
TANISHITA Kazuo
金额：
$ 8.32万
依托单位：
Keio University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

项目摘要

The gas is exchanged in the airway due to the oscillatory flow and the gas exchange mechanisms are affected by various factors such as morphology of airway, opening of airway, surfactant secreted on the inner surface of airway and others. In the natural lung, the gas exchange process is remarkably efficient and is highly sensitive to the oxygen demand, thus it is necessary to clarify the gas exchange process in the airway. In the airway, the gas is transported by the ocillatory flow in the multi-branching network and the secondary flow induced in the curved portion of bifurcating tube causes to enhance the gas transfer process, and this process is called "convective resonance". So we payed attention to the phenomena of convective resonance and the purpose of this study it to clarify the fluid mechanical feature of convective resonance causing to enhance the gas transfer in the natural lung. The convective resonance may be effective to the high frequency oscillation technology and artificial ventilation will become more effective by utilizing the effect of convetive resonance. In this study we performed both experiments and numerical studies to confirm the effectiveness of convective resonance due to the secondary flow in the curved portions. We also took into acount the effect of distensibility of the airway and constructed the realistic airway model. The distensibility of the airway will restrict the generation of turbulence, which affects the enhancement of gas transfer in the airway.

气道内气体因振荡流动而发生交换，气体交换机制受气道形态、气道开口、气道内表面分泌的表面活性剂等多种因素的影响。在自然肺中，气体交换过程非常高效，对氧气需求高度敏感，因此有必要阐明气道内的气体交换过程。在气道内，气体通过多分支网络中的振荡流动进行输送，分叉管弯曲部分诱导的二次流使气体传递过程增强，这一过程被称为“对流共振”。因此，我们关注对流共振现象，本研究的目的是阐明对流共振引起的增强自然肺内气体传递的流体力学特征。对流共振可能对高频振荡技术有效，利用对流共振的效果将使人工通风更加有效。在本研究中，我们通过实验和数值研究来证实由于二次流在弯曲部分对流共振的有效性。我们还考虑了气道扩张的影响，构建了真实的气道模型。气道的扩张性会限制湍流的产生，从而影响气道内气体传递的增强。