Integrated studies on signaling and physiological function of green tea catechin through the catechin receptor

绿茶儿茶素通过儿茶素受体的信号传导和生理功能的综合研究

• 批准号: 18208012
• 负责人: TACHIBANA Hirofumi
• 金额: $ 27.79万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18208012/
• 关键词: EGCG; 緑茶; 受容体; シグナリング; 67LR; カテキン; 機能性; 炎症制御; TLR4; Tollip; 感知遺伝子; マクロファージ; ATRA; がん予防; 分子標的; MYPT1; 感受性; がん予坊; eEF1a; シグナル; がん

67-kDa laminin receptor (67LR) has been identified as a cell surface receptor for green tea polyphenol (-)-epigallocatechin-3-gallate(EGCG)that mediates the anticancer activity of EGCG. Eukaryotic translation elongation factor 1A (eEF1A) and myosin phosphatase targeting subunit 1(MYPT1) have been identified as components responsible for the anticancer activity of EGCG in vivo. We identified functional motif on the extracellular domain of 67LR for exerting EGCG action. We also found that 67LR mediates anti-allergic and anti-inflammatory activities of EGCG, and clarified the molecular basis for the EGCG action though the receptor.

67-kDa层粘连蛋白受体（67 LR）已被鉴定为介导EGCG的抗癌活性的绿色茶多酚（-）-表没食子儿茶素-3-没食子酸酯（EGCG）的细胞表面受体。真核翻译延伸因子1A（eEF 1A）和肌球蛋白磷酸酶靶向亚基1（MYPT 1）已被鉴定为负责EGCG体内抗癌活性的组分。我们鉴定了67 LR胞外结构域上发挥EGCG作用的功能基序。我们还发现67 LR介导了EGCG的抗过敏和抗炎活性，阐明了EGCG通过受体发挥作用的分子基础。

项目成果

栄養学研究の最前線

营养研究的前沿

• 发表时间: 2008
• 作者: 加藤茂明;高田伊知郎;中村貴;山本陽子;今井祐記
• 通讯作者: 今井祐記