Integrated studies on signaling and physiological function of green tea catechin through the catechin receptor

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67-kDa laminin receptor (67LR) has been identified as a cell surface receptor for green tea polyphenol (-)-epigallocatechin-3-gallate(EGCG)that mediates the anticancer activity of EGCG. Eukaryotic translation elongation factor 1A (eEF1A) and myosin phosphatase targeting subunit 1(MYPT1) have been identified as components responsible for the anticancer activity of EGCG in vivo. We identified functional motif on the extracellular domain of 67LR for exerting EGCG action. We also found that 67LR mediates anti-allergic and anti-inflammatory activities of EGCG, and clarified the molecular basis for the EGCG action though the receptor.