Chemical Biology in internalization of membrane-permeable peptides

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Involvement of macropinocytosis to the internalization of arginine-rich membrane-permeable peptides has been suggested. In this study, using an R12 peptide bearing diazirine-based photo-reactive crosslinkers, a potential receptor to induce macropinocytosis by the interaction with R12 was identified. It was also elucidated that internalization efficiency of arginine-rich peptides are greatly affected by the peptide concentration, presence of serum, addition of hydrophobic segments and so on.