Crosstalk among cells and molecules during bone regeneration
Crosstalk among cells and molecules during bone regeneration
批准号:
19209057
负责人:
YAMAGUCHI Akira
金额:
$31.78万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
We conducted experiments to elucidate cellular and molecular crosstalk during bone regeneration, and the following results were demonstrated. 1) Notch signal regulates osteoblast differentiation and bone formation, 2) CCN3 expression was greatly increased during bone regeneration, and CCN3 regulated osteoblast differentiation by crosstalk with BMP and Notch signals, 3) Crosstalk among oral cancer cells, fibroblastic cells interfacing bone surface and osteoclasts plays important roles in bone destruction by oral cancer. 4) Latexin is involved in chondrocyte differentiation during bone development and regeneration through BMP-Sox9 cascade, 5) BMP signaling is involved in pathobiology of sunovialchondromatosis.
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DOI:
10.1177/154405910808700405
发表时间:
2008-04-01
期刊:
JOURNAL OF DENTAL RESEARCH
影响因子:
7.6
作者:
[Kitaura, H., Yoshimatsu, M., Yoshida, N.]
通讯作者:
Yoshida, N.
Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function
Ihh/Gli2 信号通过调节 Runx2 表达和功能促进成骨细胞分化
DOI:
--
发表时间:
2007
期刊:
Mol Biol Cell 18
影响因子:
--
作者:
[Shimoyama A, Wada M, Ikeda F, Hata K, Matsubara T, Nifuji A, Noda M, Amano K, Yamaguchi A, Nishimura R, Yoneda T]
通讯作者:
Yoneda T
Hyaluronic Acid Promotes the Expression of LYVE-1 in in vitro Model of Lymphangiogenesis
透明质酸促进体外淋巴管生成模型中LYVE-1的表达
DOI:
--
发表时间:
2007
期刊:
Akita J Medi 33
影响因子:
--
作者:
[Ota H, Katsube K, Ogawa J, Yanagishita M]
通讯作者:
Yanagishita M
DOI:
10.1002/jcb.21929
发表时间:
2008-12-01
期刊:
JOURNAL OF CELLULAR BIOCHEMISTRY
影响因子:
4
作者:
[Kitazawa, Riko, Mori, Kiyoshi, Kitazawa, Sohei]
通讯作者:
Kitazawa, Sohei
水棲動物と陸棲動物における骨代謝の類似点と相違点、宇宙基礎医学生物学研究に用いるべき最適なモデル生物に関するワークショップ
关于水生和陆生动物骨代谢的异同以及空间基础医学生物学研究的最佳模式生物研讨会。
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[檜山英三, 家原知子, 福澤正洋, ら, 山口朗]
通讯作者:
山口朗
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Challenge to clarify the acquirement of osteonetwork
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Spin current manipulation for highly spin-polarized superfluid helium-3
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Chip chiral separation based on specific molecular transport inside nanofluidic channel
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Direct observation of dynamics on nanoscale magnets: Development of SQUID magnetometers
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Layered Bayes Model and Information Criteria for Rare Event Risk Analysis
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High temperature metamorphism on planetesimals and protoplanetary crust
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Autoantibody dependent inflammatory response is a new therapeutic target for the GM2 gangliosidoses
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Comprehensive analysis of bone formation and its application
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DEVELOPMENT OF A NEW THERAPEUTC APPROCH TO BONE REGENERATION FOR GENE THERAPY
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Development of a therapeutic method of bone repair using BMP responding mesencbymal cells
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Multivariate analysis of chemotherapeutic effect for oral cancer by tumor markers
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Morphological and molecular analyses of bone repair
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Role of BMP in fracture repair
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海外基金