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Crosstalk among cells and molecules during bone regeneration

Crosstalk among cells and molecules during bone regeneration
骨再生过程中细胞和分子之间的串扰
批准号:
19209057
负责人:
YAMAGUCHI Akira
金额:
$31.78万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009

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中文摘要
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英文摘要
We conducted experiments to elucidate cellular and molecular crosstalk during bone regeneration, and the following results were demonstrated. 1) Notch signal regulates osteoblast differentiation and bone formation, 2) CCN3 expression was greatly increased during bone regeneration, and CCN3 regulated osteoblast differentiation by crosstalk with BMP and Notch signals, 3) Crosstalk among oral cancer cells, fibroblastic cells interfacing bone surface and osteoclasts plays important roles in bone destruction by oral cancer. 4) Latexin is involved in chondrocyte differentiation during bone development and regeneration through BMP-Sox9 cascade, 5) BMP signaling is involved in pathobiology of sunovialchondromatosis.
期刊论文(84)
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会议论文
DOI: 10.1177/154405910808700405
发表时间: 2008-04-01
期刊: JOURNAL OF DENTAL RESEARCH
影响因子: 7.6
作者: [Kitaura, H., Yoshimatsu, M., Yoshida, N.]
通讯作者: Yoshida, N.
Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function
Ihh/Gli2 信号通过调节 Runx2 表达和功能促进成骨细胞分化
DOI: --
发表时间: 2007
期刊: Mol Biol Cell 18
影响因子: --
作者: [Shimoyama A, Wada M, Ikeda F, Hata K, Matsubara T, Nifuji A, Noda M, Amano K, Yamaguchi A, Nishimura R, Yoneda T]
通讯作者: Yoneda T
Hyaluronic Acid Promotes the Expression of LYVE-1 in in vitro Model of Lymphangiogenesis
透明质酸促进体外淋巴管生成模型中LYVE-1的表达
DOI: --
发表时间: 2007
期刊: Akita J Medi 33
影响因子: --
作者: [Ota H, Katsube K, Ogawa J, Yanagishita M]
通讯作者: Yanagishita M
DOI: 10.1002/jcb.21929
发表时间: 2008-12-01
期刊: JOURNAL OF CELLULAR BIOCHEMISTRY
影响因子: 4
作者: [Kitazawa, Riko, Mori, Kiyoshi, Kitazawa, Sohei]
通讯作者: Kitazawa, Sohei
63
    Fundamental research of practical use of Super Fine Silica Powder Slurry Materials for countermeasure against liquefaction
    • 批准号:
      26420485
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.83万
    • 财政年份:
      2014
    • 负责人:
      YAMAGUCHI Akira
    • 依托单位:
    Involvement in alpha-synuclein function and pathology in lysosomal storage diseases
    • 批准号:
      25460500
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.24万
    • 财政年份:
      2013
    • 负责人:
      YAMAGUCHI Akira
    • 依托单位:
    Development of micro-SQUID-NMR for low temperature condensed matter physics
    • 批准号:
      24654109
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2012
    • 负责人:
      YAMAGUCHI Akira
    • 依托单位:
    Elucidation of the mechanisms underlying in the immunological abnormalities of lysosomal storage diseases
    • 批准号:
      23790448
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.83万
    • 财政年份:
      2011
    • 负责人:
      YAMAGUCHI Akira
    • 依托单位:
    海外基金