Crosstalk among cells and molecules during bone regeneration

骨再生过程中细胞和分子之间的串扰

• 批准号: 19209057
• 负责人: YAMAGUCHI Akira
• 金额: $ 31.78万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19209057/
• 关键词: 骨芽細胞; 破骨細胞; BMP; Notch; CCN3; 口腔癌; 骨再生; 骨形成; 骨リモデリング; 骨吸収; 全身性因子; Wnt

We conducted experiments to elucidate cellular and molecular crosstalk during bone regeneration, and the following results were demonstrated. 1) Notch signal regulates osteoblast differentiation and bone formation, 2) CCN3 expression was greatly increased during bone regeneration, and CCN3 regulated osteoblast differentiation by crosstalk with BMP and Notch signals, 3) Crosstalk among oral cancer cells, fibroblastic cells interfacing bone surface and osteoclasts plays important roles in bone destruction by oral cancer. 4) Latexin is involved in chondrocyte differentiation during bone development and regeneration through BMP-Sox9 cascade, 5) BMP signaling is involved in pathobiology of sunovialchondromatosis.

我们进行了实验来阐明骨再生过程中的细胞和分子串扰，并证明了以下结果。1)Notch信号调控成骨细胞分化和骨形成; 2）在骨再生过程中CCN 3表达显著增加，CCN 3通过与BMP和Notch信号的串扰调控成骨细胞分化; 3）口腔癌细胞、骨表面界面成纤维细胞和破骨细胞之间的串扰在口腔癌骨破坏中起重要作用。4)Latexin通过BMP-Sox 9级联反应参与骨发育和再生过程中软骨细胞的分化。5）BMP信号通路参与滑膜软骨瘤病的病理生物学。

项目成果

An anti-c-Fms antibody inhibits orthodontic tooth movement

• DOI: 10.1177/154405910808700405
• 发表时间: 2008-04-01
• 期刊: JOURNAL OF DENTAL RESEARCH
• 影响因子: 7.6
• 作者: Kitaura, H.;Yoshimatsu, M.;Yoshida, N.
• 通讯作者: Yoshida, N.

Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function

Ihh/Gli2 信号通过调节 Runx2 表达和功能促进成骨细胞分化

• 发表时间: 2007
• 期刊: Mol Biol Cell 18
• 作者: Shimoyama A;Wada M;Ikeda F;Hata K;Matsubara T;Nifuji A;Noda M;Amano K;Yamaguchi A;Nishimura R;Yoneda T
• 通讯作者: Yoneda T

Hyaluronic Acid Promotes the Expression of LYVE-1 in in vitro Model of Lymphangiogenesis

透明质酸促进体外淋巴管生成模型中LYVE-1的表达

• 发表时间: 2007
• 期刊: Akita J Medi 33
• 作者: Ota H;Katsube K;Ogawa J;Yanagishita M
• 通讯作者: Yanagishita M

Modulation of Mouse RANKL Gene Expression by Runx2 and Vitamin D3

• DOI: 10.1002/jcb.21929
• 发表时间: 2008-12-01
• 期刊: JOURNAL OF CELLULAR BIOCHEMISTRY
• 影响因子: 4
• 作者: Kitazawa, Riko;Mori, Kiyoshi;Kitazawa, Sohei
• 通讯作者: Kitazawa, Sohei

水棲動物と陸棲動物における骨代謝の類似点と相違点、宇宙基礎医学生物学研究に用いるべき最適なモデル生物に関するワークショップ

关于水生和陆生动物骨代谢的异同以及空间基础医学生物学研究的最佳模式生物研讨会。

• 发表时间: 2008
• 作者: 檜山英三;家原知子;福澤正洋;ら;山口朗
• 通讯作者: 山口朗