Maintenance and disturbance of osteonetwork: basic studies on clarification of pathophysiology of craniofacial bone diseases
Maintenance and disturbance of osteonetwork: basic studies on clarification of pathophysiology of craniofacial bone diseases
批准号:
22249061
负责人:
YAMAGUCHI Akira
金额:
$30.78万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
我们进行了实验,以阐明基于骨网络概念的颅面骨疾病的病理生理学,并发表了以下结果。1.发展生物影像技术,以显示成骨细胞、骨细胞及破骨细胞之间的相互关系。2.骨细胞在正畸牙齿移动中起着重要作用。3.CCN 3是骨再生的负调节因子。$. RANKL在口腔鳞状细胞癌引起的骨破坏中起重要作用。
英文摘要
We conducted experiments to clarify the pathophysiology of craniofacial bone diseases based on the concept of osteonetwork, and the following results were published. 1. Development of bioimaging techniques to visualize the netwrork among osteoblasts, osteocytes and osteoclasts. 2. Osteocytes play crucial roles in orthodontic tooth movement. 3.CCN3 is a negative regulator in bone regeneration. $. RANKL plays crucial roles in bone destruction induced by oral squamous cell carcinoma.
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オステオネットワークの維持と破綻:顎顔面骨疾患の病態解明を目指して
骨网络的维护和破坏:旨在阐明颌面骨疾病的病理学
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kadouchi I, Sakamoto K, Liu T, Murakami T, Kobayashi E, Hoshino Y, Yamaguchi A, 山口朗, 山口朗, 山口朗]
通讯作者:
山口朗
Roles of IL-6 an r in osteoc ast formation associate with oralcancers: The significance of IL-6 synthesized by stromal cells in response to cancer cells.
IL-6 在与口腔癌相关的破骨细胞形成中的作用:基质细胞合成的 IL-6 响应癌细胞的重要性。
DOI:
--
发表时间:
2010
期刊:
Amer J Pathol
影响因子:
--
作者:
[Kayamori K, Sakamoto K Nakashima T, Takayanagi T, Morita K, Omura K, Nguyen ST, Miki Y, Iimura T, Himeno A, Akashi T, Yamada-Okabe H, Ogata E, Yamaguchi A]
通讯作者:
Yamaguchi A
病理組織学的立場から見たBMA関連顎骨病変の成因と診断、口腔三学会合同シンポジウム、「Bone-modifying Agents (BMA)関連顎骨病変の病態・診断・治療」
从组织病理学角度探讨BMA相关颌骨病变的原因和诊断,三个口腔学会联合研讨会,“骨改性剂(BMA)相关颌骨病变的病理学、诊断和治疗”
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[岡敬之, 村木重之, 阿久根徹, 中村耕三, 川口浩, 吉村典子, 細田享平, 山口朗]
通讯作者:
山口朗
ビスホスホネート関連顎骨壊死(骨髄炎)、(シンポジウム:難治性骨髄炎の治療戦略)
双膦酸盐相关的颌骨坏死(骨髓炎),(研讨会:难治性骨髓炎的治疗策略)
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Otsu H, Moriyama M, 速水洋子, 山口朗]
通讯作者:
山口朗
骨形成と血管石灰化の共通点と相違点、シンポジウム「Bone andVascular Calcification」
骨形成与血管钙化的异同,研讨会“骨与血管钙化”
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[倉島孝行, 竹田晋也, 佐野真琴, 木戸雅子, 長谷千代子, 園山亘, 山口朗]
通讯作者:
山口朗
共 81 条
Fundamental research of practical use of Super Fine Silica Powder Slurry Materials for countermeasure against liquefaction
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批准号:26420485
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
-
财政年份:2014
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负责人:YAMAGUCHI Akira
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依托单位:
Involvement in alpha-synuclein function and pathology in lysosomal storage diseases
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批准号:25460500
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2013
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负责人:YAMAGUCHI Akira
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依托单位:
Development of micro-SQUID-NMR for low temperature condensed matter physics
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批准号:24654109
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
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财政年份:2012
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负责人:YAMAGUCHI Akira
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依托单位:
Elucidation of the mechanisms underlying in the immunological abnormalities of lysosomal storage diseases
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批准号:23790448
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.83万
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财政年份:2011
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负责人:YAMAGUCHI Akira
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依托单位:
Challenge to clarify the acquirement of osteonetwork
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批准号:23659854
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2011
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负责人:YAMAGUCHI Akira
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依托单位:
Spin current manipulation for highly spin-polarized superfluid helium-3
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批准号:22684019
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项目类别:Grant-in-Aid for Young Scientists (A)
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资助金额:$17.31万
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财政年份:2010
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负责人:YAMAGUCHI Akira
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依托单位:
Chip chiral separation based on specific molecular transport inside nanofluidic channel
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批准号:21685009
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项目类别:Grant-in-Aid for Young Scientists (A)
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资助金额:$17.47万
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财政年份:2009
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负责人:YAMAGUCHI Akira
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依托单位:
Direct observation of dynamics on nanoscale magnets: Development of SQUID magnetometers
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批准号:20684015
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项目类别:Grant-in-Aid for Young Scientists (A)
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资助金额:$16.14万
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财政年份:2008
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负责人:YAMAGUCHI Akira
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依托单位:
Layered Bayes Model and Information Criteria for Rare Event Risk Analysis
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批准号:20560775
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.08万
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财政年份:2008
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负责人:YAMAGUCHI Akira
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依托单位:
Crosstalk among cells and molecules during bone regeneration
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批准号:19209057
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.78万
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财政年份:2007
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负责人:YAMAGUCHI Akira
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依托单位:
High temperature metamorphism on planetesimals and protoplanetary crust
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批准号:19540511
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.66万
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财政年份:2007
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负责人:YAMAGUCHI Akira
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依托单位:
Autoantibody dependent inflammatory response is a new therapeutic target for the GM2 gangliosidoses
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批准号:19790734
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.34万
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财政年份:2007
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负责人:YAMAGUCHI Akira
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依托单位:
EVALUATION OF GRANDE OF MALLIGNANCY ON THE BASIS OF CELL CYCLE ADHESION MOLECULESIN ORAL SQUAMOUS CELL CARCUNOMA
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批准号:18592222
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.26万
-
财政年份:2006
-
负责人:YAMAGUCHI Akira
-
依托单位:
Study of Resistive Plate Chamber with high rate capability
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批准号:15540246
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.86万
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财政年份:2003
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负责人:YAMAGUCHI Akira
-
依托单位:
Comprehensive analysis of bone formation and its application
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批准号:14104015
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$72.47万
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财政年份:2002
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负责人:YAMAGUCHI Akira
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依托单位:
DEVELOPMENT OF A NEW THERAPEUTC APPROCH TO BONE REGENERATION FOR GENE THERAPY
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批准号:12557153
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.51万
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财政年份:2000
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负责人:YAMAGUCHI Akira
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依托单位:
Development of a therapeutic method of bone repair using BMP responding mesencbymal cells
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批准号:09557140
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$5.95万
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财政年份:1997
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负责人:YAMAGUCHI Akira
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依托单位:
Multivariate analysis of chemotherapeutic effect for oral cancer by tumor markers
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批准号:09470459
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.03万
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财政年份:1997
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负责人:YAMAGUCHI Akira
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依托单位:
Morphological and molecular analyses of bone repair
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批准号:09470395
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.38万
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财政年份:1997
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负责人:YAMAGUCHI Akira
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依托单位:
Role of BMP in fracture repair
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批准号:07457432
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.61万
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财政年份:1995
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负责人:YAMAGUCHI Akira
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依托单位:
海外基金