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Role of BMP in fracture repair

Role of BMP in fracture repair
BMP 在骨折修复中的作用
批准号:
07457432
负责人:
YAMAGUCHI Akira
金额:
$4.61万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
1995
资助国家:
日本
项目状态:
已结题
起止时间:
1995 至 1996

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英文摘要
1) We investigated the histological changes occurred during fracture repair of ribs in 6-week old mice. On day 3 after fracture, chondrocytes appeared at fracture sites. ALP-positive osteoblasts first appeared at the fracture sites on day 4 after fracture.2) The expression of mRNAs of BMP-2, BMP-4 and Sonic hedgehog (Shh) were up-regulated on days 1 and 2 after fracture.3) Shh induced osteoblastic differentiation in C3H10T1/2 and MC3T3-E1 cells.4) The transplantation of the fibroblasts expressing Shh into muscular sites in nude mice induced ectopic bone formation.These results demonstrated that BMPs and Shh play important roles during fracture repair.
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Ikeda T,et al.: "Cloning of rat type lreceptor mRNA for BMP-2 and BMP-4 and comparison of the ocalizalion of its ligand." Dev.Dynamics. 206. 318-329 (1996)
Ikeda T 等人:“BMP-2 和 BMP-4 的大鼠 I 型受体 mRNA 的克隆及其配体的定位比较”。
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通讯作者:
Yamaguchi A,et al.: "Ettects of BMP-2-4 and-6 on osteoblastic differentiation of bone marrow derived stromal cell lines,ST2 and MC3T3-G2/PA6." Biochem.Biophys.Res.Commun.220. 366-371 (1996)
Yamaguchi A 等人:“BMP-2-4 和 BMP-6 对骨髓源性基质细胞系 ST2 和 MC3T3-G2/PA6 成骨细胞分化的影响”。
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Yamaguchi A,et.al.: "Effects of BMP-2, -4 and -6 on osteoblastic differentiation of bone marrow derivedstromal cell lines, ST2 and MC3T3-G2/PA6." BBRC. 220. 366-371 (1996)
Yamaguchi A 等人:“BMP-2、-4 和 -6 对骨髓衍生基质细胞系 ST2 和 MC3T3-G2/PA6 成骨细胞分化的影响”。
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