Role of BMP in fracture repair
Role of BMP in fracture repair
批准号:
07457432
负责人:
YAMAGUCHI Akira
金额:
$4.61万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
1995
资助国家:
日本
项目状态:
已结题
起止时间:
1995 至 1996
中文摘要
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英文摘要
1) We investigated the histological changes occurred during fracture repair of ribs in 6-week old mice. On day 3 after fracture, chondrocytes appeared at fracture sites. ALP-positive osteoblasts first appeared at the fracture sites on day 4 after fracture.2) The expression of mRNAs of BMP-2, BMP-4 and Sonic hedgehog (Shh) were up-regulated on days 1 and 2 after fracture.3) Shh induced osteoblastic differentiation in C3H10T1/2 and MC3T3-E1 cells.4) The transplantation of the fibroblasts expressing Shh into muscular sites in nude mice induced ectopic bone formation.These results demonstrated that BMPs and Shh play important roles during fracture repair.
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Ikeda T,et al.: "Cloning of rat type lreceptor mRNA for BMP-2 and BMP-4 and comparison of the ocalizalion of its ligand." Dev.Dynamics. 206. 318-329 (1996)
Ikeda T 等人:“BMP-2 和 BMP-4 的大鼠 I 型受体 mRNA 的克隆及其配体的定位比较”。
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Yamaguchi A,et al.: "Ettects of BMP-2-4 and-6 on osteoblastic differentiation of bone marrow derived stromal cell lines,ST2 and MC3T3-G2/PA6." Biochem.Biophys.Res.Commun.220. 366-371 (1996)
Yamaguchi A 等人:“BMP-2-4 和 BMP-6 对骨髓源性基质细胞系 ST2 和 MC3T3-G2/PA6 成骨细胞分化的影响”。
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Yokose S.et al.: "An estrogen deliciency caued by ocariectomy increases plasma levels of systemic factors that stimulate proloteration and differentiation of osteblasts in rats." Endocrinology. 137. 469-478 (1996)
Yokose S.等人:“去骨术引起的雌激素缺乏会增加刺激大鼠成骨细胞增殖和分化的全身因子的血浆水平。”
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Yamaguchi A,et.al.: "Effects of BMP-2, -4 and -6 on osteoblastic differentiation of bone marrow derivedstromal cell lines, ST2 and MC3T3-G2/PA6." BBRC. 220. 366-371 (1996)
Yamaguchi A 等人:“BMP-2、-4 和 -6 对骨髓衍生基质细胞系 ST2 和 MC3T3-G2/PA6 成骨细胞分化的影响”。
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发表时间:
期刊:
影响因子:
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作者:
[]
通讯作者:
Ikeda T,et al.: "Cloning of rat type lreceptor mRNA for BMP-2 and BMP-4 and comparison of the mRNA ocalization of its ligand." Dev.Dynamics. 206. 318-329 (1996)
Ikeda T 等人:“BMP-2 和 BMP-4 的大鼠 I 型受体 mRNA 的克隆及其配体的 mRNA 定位的比较”。
DOI:
--
发表时间:
期刊:
影响因子:
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作者:
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通讯作者:
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