Molecular mechanism of the initiation of homologous recombination by meiotic cohesin

减数分裂是一种特殊类型的细胞分裂，用于有性生殖并产生配子。同源染色体之间的遗传重组是减数分裂所必需的。重组缺陷导致生物多样性下降和染色体异常引起的疾病。减数分裂染色体与各种蛋白质相互作用。这种相互作用动态地改变了染色体结构。在这项研究中，我们展示了染色体结构蛋白如何在分子水平上调节减数分裂重组的启动。

Meiosis is a special type of cell division for sexual reproduction and produces gametes. Genetic recombination between homologous chromosomes is required for meiosis. A defect in the recombination results in declining biodiversity and disorders caused by chromosomal abnormality. Meiotic chromosomes interact with various proteins. The interaction dynamically alters chromosome structure. In this study, we showed how a chromosomal structural protein regulates initiation of meiotic recombination at a molecular level.