Role of stress-activated signaling pathway in mechanical stress-induced bone remodeling

应力激活信号通路在机械应力诱导骨重塑中的作用

• 批准号: 21890014
• 负责人: MATSUI Hiroyuki
• 金额: $ 1.66万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21890014/
• 关键词: 骨免疫学; メカノバイオロジー; MAPキナーゼ; JNK・p38; NF-κB; シグナル伝達; 骨代謝

Mechanical stress to bone is important for the maintenance of bone homeostasis. Osteoblast, which performs bone formation derived from mesenchymal cells, osteoclast which is responsible for bone resorption is hematopoietic stem cell origin like as other immune cells. Thus, osteoimmunological study is increasingly needed for the interpretation of osteoblast-osteoclast interaction. This study has unveiled that TAK1 MAPKKK was activated by mechanical stretch loading in osteoblast, and induced the expression of IL-6, an osteoclastogenic factor, via its downstream signaling pathway.

骨骼的机械应力对于维持骨骼稳态很重要。成骨细胞由间充质细胞进行骨形成，破骨细胞负责骨吸收，与其他免疫细胞一样，都是造血干细胞来源。因此，越来越需要骨免疫学研究来解释成骨细胞-破骨细胞相互作用。这项研究揭示了 TAK1 MAPKKK 在成骨细胞中被机械拉伸载荷激活，并通过其下游信号通路诱导破骨细胞因子 IL-6 的表达。

项目成果

Mechanical stress induces the activation of TAK1 and its downstream pathways in pre-osteoblastic cells

机械应力诱导前成骨细胞中 TAK1 及其下游通路的激活

• 发表时间: 2009
• 作者: Fukuno N;Suzuki O;Sasaki K;Tamura S;et al.
• 通讯作者: et al.

TGF-β-activated kinase 1 mediates mechanical stress-induced IL-6 expression in osteoblasts

• DOI: 10.1016/j.bbrc.2011.02.127
• 发表时间: 2011-05-06
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Fukuno, Naoto;Matsui, Hiroyuki;Tamura, Shinri
• 通讯作者: Tamura, Shinri

Expression Patterns of Collagen Types I and III in the Capsule of a Rat Knee Contracture Model

• DOI: 10.1002/jor.20997
• 发表时间: 2010-03-01
• 期刊: JOURNAL OF ORTHOPAEDIC RESEARCH
• 影响因子: 2.8
• 作者: Hagiwara, Yoshihiro;Ando, Akira;Itoi, Eiji
• 通讯作者: Itoi, Eiji

骨芽細胞のJNKおよびp38は骨メカノバイオロジーにおいて破骨細胞とのサイトカインクロストークに寄与する

成骨细胞 JNK 和 p38 有助于骨力学生物学中细胞因子与破骨细胞的串扰

• 发表时间: 2010
• 作者: Suzuki T;Orba Y;Makino Y;Okada Y;Sunden Y;Kimura T;Hasegawa H;Sata T;Hall WW;Sawa H.;松井裕之,福野直人,神田佳明,鈴木治,武田弘資,一條秀憲,佐々木啓一,小林孝安,田村眞理
• 通讯作者: 松井裕之,福野直人,神田佳明,鈴木治,武田弘資,一條秀憲,佐々木啓一,小林孝安,田村眞理

TGF-β-activated kinase 1 mediates mechanical stress-induced IL-6

TGF-β 激活激酶 1 介导机械应力诱导的 IL-6

• 期刊: expression in osteoblasts. Biochem Biophys Res Commun.(有)
• 作者: Naoto Fukuno;Hiroyuki Matsui;Yoshiaki Kanda;Osamu Suzuki;Kunihiro Matsumoto;Keiichi Sasaki;Takayasu Kobayashi;Shinri Tamura.
• 通讯作者: Shinri Tamura.