Role of stress-activated signaling pathway in mechanical stress-induced bone remodeling

点击翻译按钮获取中文摘要

Mechanical stress to bone is important for the maintenance of bone homeostasis. Osteoblast, which performs bone formation derived from mesenchymal cells, osteoclast which is responsible for bone resorption is hematopoietic stem cell origin like as other immune cells. Thus, osteoimmunological study is increasingly needed for the interpretation of osteoblast-osteoclast interaction. This study has unveiled that TAK1 MAPKKK was activated by mechanical stretch loading in osteoblast, and induced the expression of IL-6, an osteoclastogenic factor, via its downstream signaling pathway.