Electrophysiological and neuroanatomical analyses of peripheral nerve transection-induced multiple-innervation of lemniscal fibers in the somatosensory thalamus of mice

小鼠躯体感觉丘脑的中继神经元在周围神经切断后接受异常的多个丘脑纤维支配，但新的丘脑纤维的来源和配线尚不清楚。在这项研究中，我发现了丘脑纤维异位侧支在损伤后支配邻近中继神经元的电生理学和解剖学证据。这项研究中发现的重新连接可能是丘脑感受区或去传入后幻觉变化的神经基础。

Relay neurons in the somatosensory thalamus of mice receive unusual multiple lemniscal fiber innervations after peripheral nerve transection ; however the origin and wiring of the new lemniscal fibers were unknown. In this study, I found electrophysiological and anatomical evidence for ectopic collaterals of lemniscal fibers innervating neighbor relay neurons after the injury. The rewiring found in this study may be a neural basis for changes in receptive fields in the thalamus or phantom sensations after deafferentations.