Effect of oxidative stress on disulfide bond formation of uric acid efflux transporter BCRP
Effect of oxidative stress on disulfide bond formation of uric acid efflux transporter BCRP
氧化应激对尿酸外排转运蛋白BCRP二硫键形成的影响
批准号：
22890003
负责人：
OGURA Jiro
金额：
$2.01万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Research Activity Start-up
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2011
中文摘要
翻译
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英文摘要
In this study, we investigated that oxidative stress affected BCRP expression, which is a uric acid efflux transporter. It has known that aging-induced oxidative stress is caused by activation of xanthine oxidase. Thus, we used the substrates of xanthine oxidase in this study. In Caco-2 cells, the activation of xanthine oxidase was suppressed the BCRP S-S bond formation, but not in HK-2 cells. These results suggest that the effect of oxidative stress on the efflux of uric acid is different between intestine and kidney.
期刊论文(1)
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科研奖励(0)
会议论文
(1st/14) Intestinal ischemia-reperfusion increases efflux for uric acid via paracellular route in the intestine, but decreases that via transcellular route mediated by Bcrp
(1st/14) 肠道缺血再灌注会增加肠道中尿酸通过细胞旁途径的流出，但会减少通过 Bcrp 介导的跨细胞途径的尿酸流出
(1st/14) 肠道缺血再灌注会增加肠道中尿酸通过细胞旁途径的流出，但会减少通过 Bcrp 介导的跨细胞途径的尿酸流出
DOI：
--
发表时间：
2012
期刊：
J. Pharm. Pharm. Sci
影响因子：
--
作者：
[Kato N, et al., 藤田恭之, 畑中豊,松野吉宏, Ogura J]
通讯作者：
Ogura J
Strategy for gout prevention based on pharmacodynamics and pharmacokinetics of antioxidants
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批准号：24700819
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项目类别：Grant-in-Aid for Young Scientists (B)
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资助金额：$2.83万
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财政年份：2012
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负责人：OGURA Jiro
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依托单位：
海外基金
