Development of the antibody drug production system using a highly efficient artificial chromosome vector.

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In this study, we tried development of the technology which can increase the amount of antibody production and stabilize the quality of antibody drug production cells using the artificial chromosome vector(which enable long-term stable expression of transgenes) to reduce the cost for antibody-drug production in industry.When we introduced the medicine candidate gene into the artificial chromosome vector and measured the purpose protein in a culture medium, the amount of production increased to the number of transgenes.For the future, we continue the study to increase the amount of production using gene amplification system.