Social brain function deficits and psychosis in schizophrenia and Asperger's disorder

使用功能磁共振成像(FMRI)，我进行了一系列实验，旨在识别精神分裂症和自闭症谱系障碍(ASD)(包括阿斯伯格障碍)中潜在的社交和沟通问题的神经认知机制缺陷。在精神分裂症的实验中，我们发现了听觉语言系统中的多个水平的功能异常，这些异常是幻听的基础。在ASD的实验中，我们发现选择性注意缺陷与ASD症状的严重程度之间存在显著的关联。这些发现有助于识别导致精神分裂症和自闭症的关键神经异常，这两种疾病的特征都是社交和沟通障碍。

Using functional magnetic resonance imaging(fMRI), I conducted a series of experiments that aimed to identify deficient neural cognitive mechanisms that underlie social and communicative problems in schizophrenia and autism spectrum disorders(ASD), including Asperger's disorder. In experiments for schizophrenia, we identified multiple levels of functional abnormalities in the auditory language system that underlie auditory hallucinations. In experiments for ASD, we revealed significant association between deficiency of selective attention and the severity of ASD symptoms. These findings help to identify critical neural abnormalities responsible for schizophrenia and ASD, each of which is characterized by social and communicative deficits.