Development of a new therapy for xerostomia using mechanobiology

利用机械生物学开发口干症新疗法

• 批准号: 23890195
• 负责人: KONDO Yusuke
• 金额: $ 2.08万
• 依托单位: Kyushu Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23890195/
• 关键词: 唾液腺; 顎下腺; 口腔乾燥症; メカノバイオロジー; AQP5; NKCC1

I planned this study to develop a new therapy for xerostomia using mechanobiologycombined with muscarinic agonists. As a result, it was revealed that salivary gland function is temperature-sensitive, which is associated with intracellular Ca2+concentration increase. In addition, it is also clarified that the saliva secretion is updated in hypotonic environment, and the involvement of Na+-K+-2Clcotransporter activity has been suggested as the cause.

我计划这项研究是为了开发一种新的治疗口干症的方法，使用机械生物学和毒扁豆碱激动剂相结合。结果表明，唾液腺功能对温度敏感，这与细胞内钙离子浓度升高有关。此外，还阐明了低渗环境下唾液分泌的更新，可能与Na+-K+-2ClcoTransporter活性有关。

项目成果

Tannic acid inhibits salivation from ex vivo mouse submandibular glands

单宁酸抑制离体小鼠颌下腺分泌唾液

• 发表时间: 2013
• 作者: T Mukaibo;T Nakamoto;Y Kondo;M Kidokoro;A Imamura;C Masaki and R;平田-土屋志津,寺下正道,岡本一起,北村知昭;TaroMukaibo;Tsuchiya-Hirata S;YusukeKondo;平田-土屋志津;平田志津;AtsusiImamura
• 通讯作者: AtsusiImamura

Hyperand hypo- osmolarity on submandibular glandfunction

高渗透压和低渗透压对颌下腺功能的影响

• 发表时间: 2011
• 作者: M Kidokoro;A Imamura;Y Kondo;T Mukaibo;C Masaki;R Hosokawa and T Nakamoto
• 通讯作者: R Hosokawa and T Nakamoto

Hosokawa, Thermal influence of saliva secretionex vivo in the mouse submandibular gland

Hosokawa，小鼠颌下腺离体唾液分泌的热影响

• 发表时间: 2013
• 期刊: Open Journal of Stomatology
• 作者: T Mukaibo;T Nakamoto;Y Kondo;M Kidokoro;A Imamura;C Masaki and R
• 通讯作者: C Masaki and R

Hyper- and hypo-osmolarity on submandibular gland function

高渗透压和低渗透压对颌下腺功能的影响

• 发表时间: 2011
• 作者: Manami Kidokoro;Atsushi Imamura;Yusuke Kondo;Taro Mukaibo;Chihiro Masaki;Ryuji Hosokawa;Tetsuji Nakamoto
• 通讯作者: Tetsuji Nakamoto

Thermal influence of saliva secretion ex vivo in the mouse submandibular gland

小鼠颌下腺离体唾液分泌的热影响

• DOI: 10.4236/ojst.2013.31015
• 发表时间: 2013
• 期刊: Open Journal of Stomatology
• 作者: T Mukaibo;T Nakamoto;Y Kondo;M Kidokoro;A Imamura;C Masaki and R;平田-土屋志津,寺下正道,岡本一起,北村知昭;TaroMukaibo
• 通讯作者: TaroMukaibo