Ultrasonic assessment of articular cartilage using contrast medium

使用造影剂对关节软骨进行超声评估

• 批准号: 23890234
• 负责人: HATTORI Koji
• 金额: $ 2万
• 依托单位: Konan Women's University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23890234/
• 关键词: 関節軟骨; 超音波; 造影剤

We have developed the ultrasonic evaluation system for articular cartilage. However this system could detect degeneration of cartilage surface, but could not detect biomechanical properties of all layers of articular cartilage. We investigated the effectiveness of ultrasonic contrast medium for the evaluation system of articular cartilage. The reflex echogram form articular cartilage was shown as A-mode echogram. The peak-peak value was used as a quantitative index of articualr cartilage. Cartialge sample was immersed into contrast mediul for 10 minutes and after that, the sample was immersed in saline and analyzed by the ultrasonic evaluation system.The maximum peak-peak value of samples with contrast medium was 5.3 to 9.8 times higher than the sample without contrast medium. The peak -peak value of sample with contrast medium show the maximum within 2 minutes and decreased as the duration of saline immersion increased. Our finding indicated that ultrasound analysis using contrast medium can predict the biomechanical behavior of articular cartilage.

我们开发了关节软骨超声评价系统。但该系统可以检测到软骨表面的退变，但不能检测到关节软骨各层的生物力学性能。探讨超声造影剂在关节软骨评价系统中的应用效果。关节软骨反射声像图为A型声像图。以峰峰值作为关节软骨的定量指标。Cartialge样品在对比剂中浸泡10min，然后在生理盐水中浸泡，通过超声评价系统进行分析，加入造影剂的样品的最大峰峰值是不加造影剂的样品的5.3~9.8倍。加入造影剂的样品峰值峰值在2min内达到最大值，并随生理盐水浸泡时间的延长而减小。我们的发现表明，使用造影剂的超声分析可以预测关节软骨的生物力学行为。

项目成果

Feasibility and limitations of the round robin test for assessment of in vitro chondrogenesis evaluation protocol in a tissue-engineered medical product

组织工程医疗产品体外软骨形成评估方案循环试验的可行性和局限性

• DOI: 10.1002/term.460
• 发表时间: 2011
• 期刊: JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
• 影响因子: 3.3
• 作者: Masako Yokoi;et al.
• 通讯作者: et al.

日進月歩の関節軟骨評価技術開発

快速发展的关节软骨评价技术的开发

• 发表时间: 2012
• 作者: Kato T;Hattori K;et al;竹内美樹;服部耕治
• 通讯作者: 服部耕治

Mesenchymal stromal cells improve the osteogenic capabilities of mineralized agarose gels in a rat full-thickness cranial defect model

• DOI: 10.1002/term.495
• 发表时间: 2013-01-01
• 期刊: JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
• 影响因子: 3.3
• 作者: Mizuta, Norihiko;Hattori, Koji;Yura, Yoshiaki
• 通讯作者: Yura, Yoshiaki

Bone morphogenetic protein-2 in biodegradable gelatin and β-tricalcium phosphate sponges enhances the in vivo bone-forming capability of bone marrow mesenchymal stem cells

• DOI: 10.1002/term.427
• 发表时间: 2012-04-01
• 期刊: JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
• 影响因子: 3.3
• 作者: Tadokoro, Mika;Matsushima, Asako;Ohgushi, Hajime
• 通讯作者: Ohgushi, Hajime

A comparative study of induced pluripotent stem cells generated from frozen, stocked bone marrow‐ and adipose tissue‐derived mesenchymal stem cells

• DOI: 10.1002/term.428
• 发表时间: 2012-04
• 期刊: Journal of Tissue Engineering and Regenerative Medicine
• 影响因子: 3.3
• 作者: Hiroe Ohnishi;Yasuaki Oda;T. Aoki;M. Tadokoro;Yoshihiro Katsube;H. Ohgushi;K. Hattori;S. Yuba