Regulation of Bcl-2 protein family prtoteins by virus infection
Regulation of Bcl-2 protein family prtoteins by virus infection
批准号:
24890105
负责人:
OKAMOTO Toru
金额:
$1.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Research Activity Start-up
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-08-31 至 2014-03-31
中文摘要
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英文摘要
Japanese Encephalitis virus (JEV) infection was found to degrade Mcl1, which is a prosurvival Bcl-2 protein family, through a proteasome dependent mechanism. Bcl-x deficient human cancer cell lines were induced cell death by JEV infection. On the other hands, Mcl1 deficiency was not induced cell death. These data suggested that JEV-infected cells were dependent on Bcl-x for their survive.
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DOI:
10.1128/jvi.01115-12
发表时间:
2012-08
期刊:
Journal of Virology
影响因子:
5.4
作者:
[T. Okamoto;Stephanie A. Campbell;Ninad Mehta;J. Thibault;P. Colman;M. Barry;D. Huang;M. Kvansakul]
通讯作者:
T. Okamoto;Stephanie A. Campbell;Ninad Mehta;J. Thibault;P. Colman;M. Barry;D. Huang;M. Kvansakul
DOI:
10.1021/cb3005403
发表时间:
2013-02-01
期刊:
ACS CHEMICAL BIOLOGY
影响因子:
4
作者:
[Okamoto, Toru, Zobel, Kerry, Czabotar, Peter E.]
通讯作者:
Czabotar, Peter E.
Enhanced Mcl1 stability can blunt stress-induced apoptosis, cause male sterility and promote tumorigenesis
增强的 Mcl1 稳定性可以减弱应激诱导的细胞凋亡、导致雄性不育并促进肿瘤发生
DOI:
--
发表时间:
2014
期刊:
Proc Natl Acad Sci U S A
影响因子:
--
作者:
[Okamoto T, Coultas L, Metcalf D, van Delft M, Glasser SP, Takiguchi M, Strasser A, Bouillet P, Adams JM, Hunag DCS]
通讯作者:
Hunag DCS
DOI:
10.1128/jvi.02186-12
发表时间:
2013-01-01
期刊:
JOURNAL OF VIROLOGY
影响因子:
5.4
作者:
[Katoh, Hiroshi, Okamoto, Toru, Matsuura, Yoshiharu]
通讯作者:
Matsuura, Yoshiharu
海外基金