Regulation of Bcl-2 protein family prtoteins by virus infection

病毒感染对 Bcl-2 蛋白家族蛋白的调节

• 批准号: 24890105
• 负责人: OKAMOTO Toru
• 金额: $ 1.91万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-08-31 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24890105/
• 关键词: ウイルス; 細胞死; アポトーシス; Bcl-2

Japanese Encephalitis virus (JEV) infection was found to degrade Mcl1, which is a prosurvival Bcl-2 protein family, through a proteasome dependent mechanism. Bcl-x deficient human cancer cell lines were induced cell death by JEV infection. On the other hands, Mcl1 deficiency was not induced cell death. These data suggested that JEV-infected cells were dependent on Bcl-x for their survive.

日本脑炎病毒（JEV）感染被发现通过蛋白酶体依赖机制降解Mcl 1，这是一个促生存Bcl-2蛋白家族。Bcl-x缺陷的人癌细胞系通过JEV感染诱导细胞死亡。另一方面，Mcl 1缺陷不诱导细胞死亡。这些数据表明，JEV感染的细胞的生存依赖于Bcl-x。

项目成果

Sheeppox Virus SPPV14 Encodes a Bcl-2-Like Cell Death Inhibitor That Counters a Distinct Set of Mammalian Proapoptotic Proteins

• DOI: 10.1128/jvi.01115-12
• 发表时间: 2012-08
• 期刊: Journal of Virology
• 影响因子: 5.4
• 作者: T. Okamoto;Stephanie A. Campbell;Ninad Mehta;J. Thibault;P. Colman;M. Barry;D. Huang;M. Kvansakul

Stabilizing the Pro-Apoptotic BimBH3 Helix (BimSAHB) Does Not Necessarily Enhance Affinity or Biological Activity

• DOI: 10.1021/cb3005403
• 发表时间: 2013-02-01
• 期刊: ACS CHEMICAL BIOLOGY
• 影响因子: 4
• 作者: Okamoto, Toru;Zobel, Kerry;Czabotar, Peter E.
• 通讯作者: Czabotar, Peter E.

Enhanced Mcl1 stability can blunt stress-induced apoptosis, cause male sterility and promote tumorigenesis

增强的 Mcl1 稳定性可以减弱应激诱导的细胞凋亡、导致雄性不育并促进肿瘤发生

• 发表时间: 2014
• 期刊: Proc Natl Acad Sci U S A
• 作者: Okamoto T;Coultas L;Metcalf D;van Delft M;Glasser SP;Takiguchi M;Strasser A;Bouillet P;Adams JM;Hunag DCS
• 通讯作者: Hunag DCS

Japanese Encephalitis Virus Core Protein Inhibits Stress Granule Formation through an Interaction with Caprin-1 and Facilitates Viral Propagation

• DOI: 10.1128/jvi.02186-12
• 发表时间: 2013-01-01
• 期刊: JOURNAL OF VIROLOGY
• 影响因子: 5.4
• 作者: Katoh, Hiroshi;Okamoto, Toru;Matsuura, Yoshiharu
• 通讯作者: Matsuura, Yoshiharu