BH3 profiling for regulatory T cells in patients with chronic graft-versus-host disease (cGVHD)
BH3 profiling for regulatory T cells in patients with chronic graft-versus-host disease (cGVHD)
批准号:
24890180
负责人:
KAWANO Yutaka
金额:
$1.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Research Activity Start-up
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012 至 2013
中文摘要
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英文摘要
BH3 profilings for CD4 positive regulatory (Treg) and non regulatory (Tcon) T cells were examined. Different priming between Treg and Tcon was associated to the effect of IL-2, especially on Treg, which contributes to cell survival. This profiling can explain how low dose IL-2 therapy works in patients with chronic graft-versus-host disease.
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
Low-Dose IL-2 Induces Bcl2 Expression and Resistance To Apoptosis In CD4 Regulatory T Cells
低剂量 IL-2 诱导 CD4 调节性 T 细胞中 Bcl2 表达和抗凋亡
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Kuramoto E, Ohno S, Furuta T, Unzai T, Tanaka YR, Hioki H, Kaneko T., 村瀬和幸,河野豊,Jeremy Ryanら]
通讯作者:
村瀬和幸,河野豊,Jeremy Ryanら
Differential Effects of TCR Stimulation and IL-2 On Apoptotic Pathways in CD4 Regulatory T Cells Compared to Conventional CD4 T Cells and CD8 T Cells
与传统 CD4 T 细胞和 CD8 T 细胞相比,TCR 刺激和 IL-2 对 CD4 调节性 T 细胞凋亡途径的不同影响
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Ohno S, Kuramoto E, Furuta T, Hioki H, Tanaka YR, Fujiyama F, Sonomura T, Uemura M, Sugiyama K, Kaneko T, 幣光太郎, 河野 豊,村瀬和幸,Ritz Jerome]
通讯作者:
河野 豊,村瀬和幸,Ritz Jerome
Low-dose-IL-2 induces Bcl2 expression and resistance to apoptosis in CD4 regulatory T cells.
低剂量 IL-2 诱导 Bcl2 表达并抵抗 CD4 调节性 T 细胞的凋亡。
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[村瀬和幸,河野豊, Jeremy Ryan ら]
通讯作者:
Jeremy Ryan ら
Analysis of 5-FU resistance in colon cancer using BH3 profiling
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批准号:17K07200
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.08万
-
财政年份:2017
-
负责人:KAWANO Yutaka
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依托单位:
Analysis of peripheral blood hematopoietic stemness using human hTERT-stromal cells
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批准号:19790672
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.36万
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财政年份:2007
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负责人:KAWANO Yutaka
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依托单位:
Research on experimental allergic mouse engrafted with human lymphocytes from allergic diseases
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批准号:09670833
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.54万
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财政年份:1997
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负责人:KAWANO Yutaka
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依托单位:
Research on Fe-Si-Mn-Cr alloy
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批准号:61550488
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.15万
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财政年份:1986
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负责人:KAWANO Yutaka
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依托单位:
海外基金