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BH3 profiling for regulatory T cells in patients with chronic graft-versus-host disease (cGVHD)

BH3 profiling for regulatory T cells in patients with chronic graft-versus-host disease (cGVHD)
慢性移植物抗宿主病 (cGVHD) 患者调节性 T 细胞的 BH3 分析
批准号:
24890180
负责人:
KAWANO Yutaka
金额:
$1.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Research Activity Start-up
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012 至 2013

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中文摘要
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英文摘要
BH3 profilings for CD4 positive regulatory (Treg) and non regulatory (Tcon) T cells were examined. Different priming between Treg and Tcon was associated to the effect of IL-2, especially on Treg, which contributes to cell survival. This profiling can explain how low dose IL-2 therapy works in patients with chronic graft-versus-host disease.
期刊论文(3)
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会议论文
Low-Dose IL-2 Induces Bcl2 Expression and Resistance To Apoptosis In CD4 Regulatory T Cells
低剂量 IL-2 诱导 CD4 调节性 T 细胞中 Bcl2 表达和抗凋亡
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Kuramoto E, Ohno S, Furuta T, Unzai T, Tanaka YR, Hioki H, Kaneko T., 村瀬和幸,河野豊,Jeremy Ryanら]
通讯作者: 村瀬和幸,河野豊,Jeremy Ryanら
Differential Effects of TCR Stimulation and IL-2 On Apoptotic Pathways in CD4 Regulatory T Cells Compared to Conventional CD4 T Cells and CD8 T Cells
与传统 CD4 T 细胞和 CD8 T 细胞相比,TCR 刺激和 IL-2 对 CD4 调节性 T 细胞凋亡途径的不同影响
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Ohno S, Kuramoto E, Furuta T, Hioki H, Tanaka YR, Fujiyama F, Sonomura T, Uemura M, Sugiyama K, Kaneko T, 幣光太郎, 河野 豊,村瀬和幸,Ritz Jerome]
通讯作者: 河野 豊,村瀬和幸,Ritz Jerome
Low-dose-IL-2 induces Bcl2 expression and resistance to apoptosis in CD4 regulatory T cells.
低剂量 IL-2 诱导 Bcl2 表达并抵抗 CD4 调节性 T 细胞的凋亡。
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [村瀬和幸,河野豊, Jeremy Ryan ら]
通讯作者: Jeremy Ryan ら
Analysis of 5-FU resistance in colon cancer using BH3 profiling
Analysis of peripheral blood hematopoietic stemness using human hTERT-stromal cells
  • 批准号:
    19790672
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.36万
  • 财政年份:
    2007
  • 负责人:
    KAWANO Yutaka
  • 依托单位:
Research on experimental allergic mouse engrafted with human lymphocytes from allergic diseases
  • 批准号:
    09670833
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $1.54万
  • 财政年份:
    1997
  • 负责人:
    KAWANO Yutaka
  • 依托单位:
Research on Fe-Si-Mn-Cr alloy
  • 批准号:
    61550488
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
  • 资助金额:
    $1.15万
  • 财政年份:
    1986
  • 负责人:
    KAWANO Yutaka
  • 依托单位:
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