ER stress and presbycusis

我们尝试通过给予两种不同类型的小鼠ER应激阻断剂TUDCA来治疗老年性耳聋。一种小鼠的老年性耳聋是由听觉毛细胞的进行性丧失引起的，而TUDCA不能减弱这种丧失。另一方面，通过长期连续给予TUDCA，在统计学上显著预防了部分由螺旋神经节细胞损失引起的其他类型小鼠的老年性耳聋。结果提示未来可能通过减少ER应力来减轻老年性耳聋。

We tried to treat presbycusis by giving a ER stress-blocker, TUDCA, to different two types of mice. Presbycusis in one type of mice is promoted by progressive loss of auditory hair cells, which was not able to be attenuated by administratin of TUDCA. On the other hand, presbysis in the other type of mice which is promoted partly by loss of spiral ganglion cells was statistically significantly prevented by long-term continueous administration of TUDCA. The results were suggestive of future possibility of attenuating presbycusis by reducing ER stress.