Clinical application of our developed artificial temporomandibular joint. 1)study on respiratory function, especially sleep apnea syndrome, 2)study on jaw movement
我们研制的人工颞下颌关节的临床应用。
基本信息
- 批准号:10470433
- 负责人:
- 金额:$ 8.64万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B).
- 财政年份:1998
- 资助国家:日本
- 起止时间:1998 至 2000
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
After considering three-dimensional morphometry, stress analysis, strength, abrasion resistance of human temporomandibular joints (TMJ), we have developed an artificial TMJ only in this country. We aimed to carry out real clinical application of this artificial TMJ, and to make it advanced prothese based on analysis of effects on chewing, phonation, swallowing, respiration and facial morphological change.1) The total replacement of the artificial TMJ was applied to the patients who were affected by chronic rheumatoid arthritis and whose TMJs were destroyed. All patients were doing well, and the results were sufficiently satisfactory as respect to function and form. Destroyed artificial TMJs were designed, and stress analysis in the clinic and simulation of jaw movement were carried out using finite element analysis.2) Jaw movement after the total replacement of TMJ was investigated using kinegiography. In comparison with healthy subjects, jaw movement in the patients with deformative a … More rthrosis was obviously restricted. After the surgery, it was confirmed that the opening quantity increased and that the masticatory efficiency heightened. However, anterior and lateral shift was limited. Some patients could not gain the opening quantity sufficiently, and in the patients atrophy of the opening muscle was observed using ultrasound image. The apnea over 60 seconds in the sleep disappeared in all patients.3) The mandible was deformed and transferred by the deformative jaw arthritis, and the antero-posterior diameter of the upper respiratory tract was then observed. It was clarified that the antero-posterior diameter of the upper respiratory tract was improved following to the surgery. However, the antero-posterior diameter of the upper respiratory tract tended to slightly decrease in postoperative 1-2 years. Although it was not clear on this cause, respiratory condition did not become worse.4) The effects on respiration following to the surgery : Respiratory conditions, ex. air-flowand oxygen saturation, in the patients with deformative arthrosis were analyzed quantitatively using apnea-monitor (Eden Trace). Consequently, it was shown that the respiration in the patients was improved.5) After two-and three-dimensional stress analysis was carried out using three-dimensional finite element analysis, the artificial TMJ with more strength was designed and made.6) To facilitate the mounting of artificial TMJ in the surgery and to raise the functionality of the artificial TMJ more and more, we have started in designing of the artificial TMJ of custom maid whom the patient individually suits. Less
本研究综合考虑人体颞下颌关节的三维形态测量、应力分析、强度、耐磨性等因素,研制了国内唯一的颞下颌关节人工关节。本研究旨在进行真实的临床应用,并通过对咀嚼、发声、吞咽、呼吸及面部形态改变的分析,使其成为一种先进的人工颞下颌关节假体。1)对慢性类风湿关节炎患者的颞下颌关节进行全关节置换。所有患者均表现良好,功能和形态方面的结果均令人满意。设计破坏性的人工颞下颌关节,利用有限元分析方法进行临床应力分析和下颌运动模拟。2)利用运动学方法研究全颞下颌关节置换术后下颌运动。与正常人相比,畸形性颌骨畸形患者的颌骨运动 ...更多信息 关节炎明显受限。手术后,证实了开口量增加,咀嚼效率提高。然而,前向和侧向移位有限。部分患者不能获得足够的开口量,并且在患者中使用超声图像观察到开口肌肉萎缩。所有患者睡眠呼吸暂停时间均超过60 s,均消失。3)通过变形性颌骨关节炎造成下颌骨变形移位,观察上呼吸道前后径。明确了手术后上呼吸道的前后径得到改善。术后1-2年上呼吸道前后径有轻度缩小趋势。虽然原因尚不清楚,但呼吸状况并未恶化。4)手术后对呼吸的影响:呼吸状况,例如。应用呼吸暂停监测仪(Eden Trace)对变形性关节病患者的空气流量和血氧饱和度进行定量分析。5)通过三维有限元分析进行二维和三维应力分析,设计并制作了强度更高的人工颞下颌关节。6)为方便手术中人工颞下颌关节的安装,进一步提高人工颞下颌关节的功能性,我们已经开始设计适合患者个人的定制女仆的人造颞下颌关节。少
项目成果
期刊论文数量(60)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Sugahara T., Mishima K., et al.: "Pathology of temporomandibular joint in rheumatoid arthritis."Seminar of Rheumatology XXII.Ed. Hichikawa K.. (2001)
Sugahara T.,Mishima K.,等人:“类风湿性关节炎颞下颌关节的病理学”。风湿病学研讨会 XXII.Ed。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
川本知明,菅原利夫 他: "人工顎頭置換術の顎関節部における力学的研究 第1報 二次元非線形有限要素法における力学的研究"岡山大学歯学雑誌. 19・1. 161-168 (2000)
Tomoaki Kawamoto、Toshio Sukawara 等:“人工颞下颌骨髁置换术的颞下颌关节的力学研究,第 1 部分。使用二维非线性有限元方法的力学研究”冈山大学牙科杂志 19・1(2000 年)。 )
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
菅原利夫 三島克章 他: "骨形成過程の微細骨梁構造の観察 -マイクロCTの骨質評価への使用経験-" 日本口腔外科学会雑誌. 44. 975-977 (1998)
Toshio Sukawara、Katsuaki Mishima 等:“骨形成过程中细小梁结构的观察 - 使用显微 CT 进行骨质量评估的经验”日本口腔颌面外科学会杂志 44. 975-977 (1998)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Mishima K., Sugahara T., et al: "A Case of Pai Syndrome" Plastic and Reconstructive Surgery. 103・1. 166-170 (1999)
Mishima K.,Sugahara T.,等:“Pai 综合征的案例”整形与重建外科 103・1(1999)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
川本知明,菅原利夫 他: "人工下顎頭置換術の顎関節部における力学的研究 第2報 人工下顎頭形状の違いによる比較"岡山大学歯学雑誌. 19・12. 169-174 (2000)
川本智明、菅原俊夫等:“人工下颌髁突置换术颞下颌关节区域的力学研究,第2次报告:不同形状的人工下颌髁突的比较”,冈山大学牙科杂志19・12。 174 (2000)
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
SUGAHARA Toshio其他文献
SUGAHARA Toshio的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('SUGAHARA Toshio', 18)}}的其他基金
Research on metabolic mechanism of palatal processes and cleft palate onset mechanism from genes
从基因角度研究腭突代谢机制及腭裂发病机制
- 批准号:
16K11772 - 财政年份:2016
- 资助金额:
$ 8.64万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Localization of Perlecan and Heparanase in the Epithelial
基底膜聚糖和乙酰肝素酶在上皮细胞中的定位
- 批准号:
22592269 - 财政年份:2010
- 资助金额:
$ 8.64万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Molecular and genetic analysis of osteoclast differentiantion factor and osteoclastgenesis inhibitory factor in osteoporosis and control of inhibition of bone resorption by 1, 4-dihydroxy-2-naphthoic acid(DHNA)
破骨细胞分化因子和破骨细胞生成抑制因子在骨质疏松症中的分子和遗传学分析及1, 4-二羟基-2-萘甲酸(DHNA)抑制骨吸收的控制
- 批准号:
19390516 - 财政年份:2007
- 资助金额:
$ 8.64万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
The study of molecular and gene analysis and bone metabolism-improving effect of propiomibacterium freudenreichii milk whey culture against osteoporosis.
费氏丙酸杆菌乳清培养物抗骨质疏松的分子基因分析及骨代谢改善作用研究
- 批准号:
17390538 - 财政年份:2005
- 资助金额:
$ 8.64万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Molecule gene analysis of bone absorption in bone reproduction medical care and development of bone absorption restraint medicine
骨再生医疗中骨吸收的分子基因分析及骨吸收抑制药物的开发
- 批准号:
15390614 - 财政年份:2003
- 资助金额:
$ 8.64万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
A design and manufacture using CAD and CAE system, and its clinical application
利用CAD和CAE系统设计制造及其临床应用
- 批准号:
13470435 - 财政年份:2001
- 资助金额:
$ 8.64万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
THE STUDY OF A JAW MOVEMENT BEFORE AND AFTER TOTAL TMJ REPLACEMENT
全颞下颌关节置换术前后下颌运动的研究
- 批准号:
08457548 - 财政年份:1996
- 资助金额:
$ 8.64万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of a simulator for educational oral surgery using virtual reality
使用虚拟现实开发口腔外科教育模拟器
- 批准号:
08557115 - 财政年份:1996
- 资助金额:
$ 8.64万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Development of artificial tempolomandibular joint
人工颞下颌关节的研制
- 批准号:
05557090 - 财政年份:1993
- 资助金额:
$ 8.64万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research (B)
Investigation into Pre and Post Operative Functional Changes of Jaw Movement and Oral Cavity Related Muscles of Maxillofacial Deformaties.
颌面畸形下颌运动和口腔相关肌肉手术前后功能变化的调查。
- 批准号:
04454501 - 财政年份:1992
- 资助金额:
$ 8.64万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
相似国自然基金
Autoimmune diseases therapies: variations on the microbiome in rheumatoid arthritis
- 批准号:31171277
- 批准年份:2011
- 资助金额:60.0 万元
- 项目类别:面上项目
Molecular Interaction Reconstruction of Rheumatoid Arthritis Therapies Using Clinical Data
- 批准号:31070748
- 批准年份:2010
- 资助金额:34.0 万元
- 项目类别:面上项目
相似海外基金
Tissue tropism of PD-1 therapy in ulcerative colitis and rheumatoid arthritis
PD-1治疗溃疡性结肠炎和类风湿性关节炎的组织向性
- 批准号:
MR/Y009681/1 - 财政年份:2024
- 资助金额:
$ 8.64万 - 项目类别:
Fellowship
Do autoantibodies to aberrantly glycosylated MUC1 drive extra-articular rheumatoid arthritis, and can GSK assets prevent driver antigen formation?
针对异常糖基化 MUC1 的自身抗体是否会导致关节外类风湿性关节炎,GSK 资产能否阻止驱动抗原形成?
- 批准号:
MR/Y022947/1 - 财政年份:2024
- 资助金额:
$ 8.64万 - 项目类别:
Research Grant
The delivery of miR-9 and RasGRP4 siRNA via high selectivity bispecific antibody conjugated lactosome: Targeting therapy for rheumatoid arthritis (RA) active synovial macrophage and osteoclast
通过高选择性双特异性抗体缀合乳糖体递送 miR-9 和 RasGRP4 siRNA:类风湿性关节炎 (RA) 活性滑膜巨噬细胞和破骨细胞的靶向治疗
- 批准号:
24K19237 - 财政年份:2024
- 资助金额:
$ 8.64万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Development of an adaptive platform trial to prevent Rheumatoid Arthritis in partnership with First Nations People.
与原住民合作开发预防类风湿关节炎的适应性平台试验。
- 批准号:
491810 - 财政年份:2023
- 资助金额:
$ 8.64万 - 项目类别:
Operating Grants
DEMORA: DEep spatial characterization of synovial MacrOphages in Rheumatoid Arthritis
DEMORA:类风湿性关节炎滑膜巨噬细胞的深度空间特征
- 批准号:
EP/Y027760/1 - 财政年份:2023
- 资助金额:
$ 8.64万 - 项目类别:
Fellowship
Novel first-in-class Therapeutics for Rheumatoid Arthritis
类风湿关节炎的一流新疗法
- 批准号:
10696749 - 财政年份:2023
- 资助金额:
$ 8.64万 - 项目类别:
Fibroblast-mediated inflammatory resolution of rheumatoid arthritis
成纤维细胞介导的类风湿性关节炎炎症消退
- 批准号:
10604629 - 财政年份:2023
- 资助金额:
$ 8.64万 - 项目类别:
A Potent D-peptide Inhibitor of TNFα for Treatment of Rheumatoid Arthritis
一种有效的 TNFα D 肽抑制剂,用于治疗类风湿性关节炎
- 批准号:
10822182 - 财政年份:2023
- 资助金额:
$ 8.64万 - 项目类别:
The roles and mechanisms of inflammation resolution in the development of Rheumatoid Arthritis
炎症消退在类风湿关节炎发展中的作用和机制
- 批准号:
10733789 - 财政年份:2023
- 资助金额:
$ 8.64万 - 项目类别:
Microbial metabolites impacting the response to methotrexate in rheumatoid arthritis
微生物代谢物影响类风湿性关节炎对甲氨蝶呤的反应
- 批准号:
10578433 - 财政年份:2023
- 资助金额:
$ 8.64万 - 项目类别: