权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Development of artificial tempolomandibular joint

人工颞下颌关节的研制

基本信息

批准号：
05557090
负责人：
SUGAHARA Toshio
金额：
$ 10.82万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1995
项目状态：
已结题

项目摘要

When the deformation and the destruction on each joint of the body occurs due to aging or various diseases, the total replacement of the joint may be adopt for morphological and functional reconstruction. However, an alloplastic temporo-mandibular joint (TMJ) components have not developed in Japan yet, and no effedtive treatment exists for the functional disorder originated in a structural destruction of TMJ.In this study, we measured the forms of human TMJs and analyzed them dynamically under mastication to develop a alloplastic TMJ for Japanese patient. Furthermore, we manufactured the prototype and applied it clinically to examine the masticatory efficiency, the movement and the frictional wear of TMJ.Then, the alloplastic TMJ components was accomplished improving the prototypes.Three-dimensional (3D) morphometory of TMJs were performed with 3D-computed tomography (CT) or dry skulls from autopsy using the high accuracy 3D measuring apparatus. The stress on the TMJ under mastication was calculated from the surface forms of condyle and fossa obtained from measurements. Then, proper bio-materials were selected, an appropriate shape of alloplastic TMJ was designed and manufactured for trial. For clinical applications, the rheumatoid arthritis with destruction of TMJ which had masticatory disorder and obstructive sleep apnea syndrome, and the congenital hypoplasia of TMJs were adopted. The masticatory function was investigated by food trituration test, and the wear degree and movement of the alloplastic TMJ components were checked up by cineradiography and ultrasonography after operation. From these data, we designed it again and now are carrying out the material fatigue test. After that we will apply it again clinically.

当人体各关节因老化或各种疾病而发生变形、破坏时，可采用关节全置换的方法进行形态和功能重建。然而，同种异体颞下颌关节(TMJ)假体在日本还没有开发出来，也没有有效的治疗方法来治疗由TMJ结构破坏引起的功能障碍。在此基础上，制作了样机，并将其应用于临床，检测了TMJ的咀嚼效率、运动和摩擦磨损情况。然后，对样机进行了改进，制作了同种异体TMJ假体。根据测量得到的髁突和颅窝的表面形态，计算出咀嚼时TMJ上的应力。然后，选择合适的生物材料，设计并制作出合适形状的同种异体TMJ进行实验。临床应用采用类风湿性关节炎伴TMJ破坏，伴有咀嚼功能障碍和阻塞性睡眠呼吸暂停综合征，TMJ先天发育不全。术后通过食物磨耗试验观察咀嚼功能，并通过X线摄片和超声检查同种异体TMJ义齿的磨损程度和运动情况。根据这些数据，我们重新设计了它，现在正在进行材料疲劳试验。之后，我们将再次将其应用于临床。