Catalytic Asymmetric Total Synthesis of Several Biologically Active Natural Products

该项目涉及开发新的催化对映选择反应，并将其应用于催化不对称合成生物活性天然产物，如士的宁、worwormannin和phobol酯。利用杂双金属配合物（如ALB或la - BINOL）催化的对映选择性Michael反应，建立了一条实用的士的宁中间体合成路线。利用分子内对映选择性Heck反应的动力学拆分，合成了worwormannin的合成中间体。目前正在对这些重要生物化合物的全合成进行进一步的研究。

The project involves a development of new catalytic enantioselective reactions, and their application to a catalytic asymmetric synthesis of biologically active natural products, such as strychnine, wortmannin and phorbol ester. Using the catalytic enantioselective Michael reaction by heterobimetallic complexes, such as ALB or La-linked BINOL, a practical synthetic route for the intermediate of strychynine was established. Using a kinetic resolution by an enantioselective intramolecular Heck reaction, a synthetic intermediate of wortmannin was developed. Further investigations toward the total synthesis of these biologically important compounds are currently ongoing.