Development of New Stereoselective Reaction and its Application

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We have succeeded in development of the new stereoselective reactions and their application to the synthesis of biologically important compounds as follows.1. The stereocontrolled synthesis of aryl-substituted exocyclic olefins has been achieved for the first time by utilizing naphthalene・Cr (CO)_3 catalyzed isomerization of conjugated dienes as a key step.2. The stereocontrolled synthesis of silyl dienol ethers having E, Z-configurations has been achieved for the first time by utilizing naphthalene・Cr (CO)_3 catalyzed isomerization of conjugated dienes.3. A highly efficient synthesis of antiulcer nileprost has been achieved by utilizing reduction-isomerization reaction of the conjugated dienes.4. Cu (I) OTf has been found to be an extremely useful reagent for the synthesis of beta-lactams from beta-amino thiol esters.5. The eastern part of azadirachtin has been synthesized starting with malic acid.6. A catalytic asymmetric synthesis of cis-decalin derivatives has been achieved by utilizing Heck-type reaction of prochiral alkenyl iodides.