Catalytic Asymmetric Synthesis of Biologically Important Molecules

我们以前开发了一种不对称Heck反应，其中顺式十氢萘衍生物在45%ee下得到。现在我们成功地改进了上述不对称Heck反应，如下所示。此外，我们利用不对称Heck反应实现了capnellenol 5和6的催化不对称合成。另一方面，已经发现通过π-烯丙基钯中间体以83%ee合成顺式-十氢萘衍生物7。

Previously we developed an asymmetric Heck reaction, in which the cis-decalin derivative was obtained in 45% ee. Now we have succeeded in improving the above-mentioned asymmetric Heck reaction as shown below.Furthermore, we have accomplished a catalytic asymmetric synthesis of capnellenols 5 and 6 by utilizing an asymmetric Heck reaction. On the other hand, the cis-decalin derivative 7 has been found to be synthesized in 83% ee through the pi-allylpalladium intermediate.