Development and Application of the Conceptionally New Catalytic Asymmetric Aldol Reaction

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Developing a catalytic asymmetric aldol reaction is a formidal challenge nowadays. Chiral Lewis acid catalysts have been reported. However, this approach still has many problems in versatility and applicability. Thus, we investigated novel approach by using the chiral palladium catalyst. We have found that the aldol reaction proceeds in high yield and ee via the palladium enolate even in the presence of small amount of water. Furthermore, we have investigated and determined the catalyst structure and the reaction mechanism.