Innovative Asymmetris Synthesis of Pharmaceuticals Through Strategic Development of Multifunctional and Multimetallic Catalysts

本研究的目的是在详细的机理分析的基础上，合理设计和开发协同型多金属催化剂，并将其应用于治疗药物的对映选择性合成。通过对基于三种不同手性配体平台的新型多金属催化剂的鉴定，发现了一些新的催化不对称反应。这些催化剂的合成用途最终导致了药物的对映选择性合成，包括达菲、瑞乐沙和立普妥。

The aim of this research project is rational design and development of cooperative multimetallic catalysts based on detailed mechanistic analysis, and their application to the enantioselective synthesis of therapeutics. A number of novel catalytic asymmetric reactions have been revealed through the identification of new multimetallic catalysts based on three different chiral ligand platforms. The synthetic utility of these catalysts culminated in the enantioselective synthesis of phamaceuticals including tamiflu, relenza, and lipitor.