Innovative Asymmetris Synthesis of Pharmaceuticals Through Strategic Development of Multifunctional and Multimetallic Catalysts

本课题的研究目的是在详细的机理分析的基础上，合理设计和开发协同多金属催化剂，并将其应用于治疗药物的对映选择性合成。通过鉴定基于三种不同手性配体平台的新型多金属催化剂，揭示了许多新的催化不对称反应。这些催化剂的合成效用在包括达菲、瑞沙和立普妥在内的药物的对映选择性合成中达到顶峰。

The aim of this research project is rational design and development of cooperative multimetallic catalysts based on detailed mechanistic analysis, and their application to the enantioselective synthesis of therapeutics. A number of novel catalytic asymmetric reactions have been revealed through the identification of new multimetallic catalysts based on three different chiral ligand platforms. The synthetic utility of these catalysts culminated in the enantioselective synthesis of phamaceuticals including tamiflu, relenza, and lipitor.