Synthetic Study on Homoisocarbacyclin

高异碳环素的合成研究

• 批准号: 03557092
• 负责人: SHIBASAKI Masakatsu
• 金额: $ 5.57万
• 依托单位: University of Tokyo (1992-1993)Hokkaido University (1991)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03557092/
• 关键词: Carbacyclin; Isocarbacyclin; Chemically Stable Prostacyclin Analog; Inhibitor of platelet aggregation; プロスタサイクリン安定類縁体; プロスタグランジン; 循環器疾患薬; ヒドリンダン骨格

In order to develop a new drug many homoisocarbacyclin analogs have beensynthesized. Anong those1-9, the homoisocarbacyclin amalog 7 has been selected as a candidate for further investigation.

为了开发新药，人们合成了许多高异碳环素类似物.其中高异碳环素Amp17被选为进一步研究的候选化合物。

项目成果

M.Shibasaki, A.Takahashi, T.Aoki, H.Sato, S.Yamada, M.Kudo, K.Kogi, and S.Narita: "A Novel Homoisocarbacyclin Analog with Potent and Long-Lasting Activity"" Chem.Pharm.Bull. 40. 279-281 (1992)

M.Shibasaki、A.Takahashi、T.Aoki、H.Sato、S.Yamada、M.Kudo、K.Kogi 和 S.Narita：“一种具有有效且持久活性的新型同异碳环素类似物”Chem.Pharm

S.Narita, A.Takahashi, H.Sato, T.Aoki, S.Yamada, and M.Shibasaki: "An Improved Method for the Introduction of Carbon-Carbon Triple Bond at C-13 in PG Synthesis" Tetrahedron Lett.33. 4041-4045 (1992)

S.Narita、A.Takahashi、H.Sato、T.Aoki、S.Yamada 和 M.Shibasaki：“在 PG 合成中在 C-13 处引入碳-碳三键的改进方法”Tetrahedron Lett.33

S.Narita: "An Improved Method for the Introduction of Carbon-Carbon Triple Bond at C-13 in PG Synthesis" Tetrahedron Lett.33. 4041-4044 (1992)

S.Narita：“在 PG 合成中在 C-13 处引入碳-碳三键的改进方法”Tetrahedron Lett.33。

M.Shibasaki: "A Novel Homoisocarbacyclin Analog with Potent and Long-Lasting Activity" Chem.Pharm.Bull.40. 279-281 (1992)

M.Shibasaki：“一种具有有效且持久活性的新型同异碳环素类似物”Chem.Pharm.Bull.40。

S.Narita: "An Imroved Method for the Introduction of Carbon-Carbon Triple Bond at C-13 in PG Synthesis" Tetrahedron Lett.33. 4041-4045 (1992)

S.Narita：“在 PG 合成中在 C-13 处引入碳-碳三键的改进方法”Tetrahedron Lett.33。