The effect of fetal cerebral white matter injury on the development of oligodendroglial linages in chronically instrumented premature fetal sheep
胎儿脑白质损伤对长期仪器化早产胎羊少突胶质细胞系发育的影响
基本信息
- 批准号:21591407
- 负责人:
- 金额:$ 2.83万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2009
- 资助国家:日本
- 起止时间:2009 至 2011
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
To determine the effect of cerebral ischemia and/or intrauterine inflammation on the development of oligodendroglial lineage in cerebral white matter, chronically instrumented fetal sheep was induced hemorrhagic hypotensionand/ornecrotizing funifitis. The brain was performed immunohistochemistry of NG2, O4, CNPase and PLP and then integrated density of each stain was statistically compared. The results suggested that in the premature fetal sheep, cerebral ischemia and/or intrauterine inflammation accelerated the oligodendroglial maturity from precursor to post-mitotic cells rather than induced apoptosis to precursor cells in the cerebral white matter.
为了确定脑缺血和/或宫内炎症对脑白质中少突胶质细胞谱系发育的影响,长期使用仪器的胎羊被诱导出血性低血压和/或坏死性真菌炎。对大脑进行NG2、O4、CNPase和PLP的免疫组化,然后统计比较各染色的积分密度。结果表明,在早产胎羊中,脑缺血和/或宫内炎症加速了少突胶质细胞从前体细胞到有丝分裂后细胞的成熟,而不是诱导脑白质中前体细胞的凋亡。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Diffuse white matter injury ofprematurebrain in the chronicallyinstrumented fetal sheep
长期检测胎羊早产脑弥漫性白质损伤
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:RyutaKitanishi;Tadashi Matsuda;Masatoshi Saito;TakushiHanita;Tatsuya Watanabe;Yoshiyasu Kobayashi;Nobuo Yaegashi
- 通讯作者:Nobuo Yaegashi
新生児の慢性肺疾患.今日の治療指針2010版
新生儿慢性肺病今日治疗指南2010年版
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:西巻滋、島義雄;安ひろみ、佐藤美保、岩崎志穂,岩崎志穂、堀口晴子堀口晴子、関和男、横田俊平横;松田直;松田直
- 通讯作者:松田直
Diffuse white matter injury of prematurebrain in the chronicallyinstrumented fetal sheep
长期检测胎羊早产脑弥漫性白质损伤
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:RyutaKitanishi;Tadashi Matsuda;Masatoshi Saito;TakushiHanita;Tatsuya Watanabe;Yoshiyasu Kobayashi;Nobuo Yaegashi
- 通讯作者:Nobuo Yaegashi
新生児.「これならわかる産科学」
《你能懂的产科》
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:Aoki R;Yokoyama U;Iwasaki S;Nishimaki S;Yokota S;Ishikawa Y;Minamisawa S;松田直
- 通讯作者:松田直
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MATSUDA Tadashi其他文献
STAP-2 positively modulates TCR-mediated Tcell activation
STAP-2 正向调节 TCR 介导的 T 细胞激活
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
SAITOH Kodai;Kashiwakura Jun-ichi;YOSHIMURA Akihiko;ORITANI Kenji;MATSUDA Tadashi - 通讯作者:
MATSUDA Tadashi
Kruppel-associated box-associated protein 1 regulates TNF-α-induced IL-6 expression via STAT3
Kruppel 相关盒相关蛋白 1 通过 STAT3 调节 TNF-α 诱导的 IL-6 表达
- DOI:
- 发表时间:
2011 - 期刊:
- 影响因子:0
- 作者:
TOGI Sumihito;MUROMOTO Ryuta;SEKINE Yuichi;MATSUDA Tadashi - 通讯作者:
MATSUDA Tadashi
CCR7 is involved in BCR-ABL/STAP-2-mediated cell growth in hematopoietic cells
CCR7 参与 BCR-ABL/STAP-2 介导的造血细胞生长
- DOI:
- 发表时间:
2015 - 期刊:
- 影响因子:0
- 作者:
INAGAKI Takuya;IWAKAMI Masashi;KITAI Yuichi;MUROMOTO Ryuta;KON Shigeyuki;SEKINE Yuichi;ORITANI Kenji;MATSUDA Tadashi - 通讯作者:
MATSUDA Tadashi
Caspase-dependent regulation of theprotein level of Epstein-Barr virus-derived latent membrane protein 1
EB 病毒来源的潜伏膜蛋白 1 蛋白水平的半胱天冬酶依赖性调节
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:0
- 作者:
HATANO Yosuke;TOGI Sumihito;MUROMOTO Ryuta;KON Shigeyuki;ORITANI Kenji;MATSUDA Tadashi - 通讯作者:
MATSUDA Tadashi
Analysis of signal transducing adaptor protein-2(STAP-2) in T cell activation
信号转导衔接蛋白2(STAP-2)在T细胞激活中的分析
- DOI:
- 发表时间:
2015 - 期刊:
- 影响因子:0
- 作者:
SAITOH Kodai;KON Shigeyuki;SEKINE Yuichi;MUROMOTO Ryuta;KITAI Yuichi、YOSHIMURA Akihiko;ORITANI Kenji;MATSUDA Tadashi - 通讯作者:
MATSUDA Tadashi
MATSUDA Tadashi的其他文献
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{{ truncateString('MATSUDA Tadashi', 18)}}的其他基金
Development of a vicarious endoscopic surgery education system based augmented reality
基于增强现实的替代内窥镜手术教育系统的开发
- 批准号:
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- 资助金额:
$ 2.83万 - 项目类别:
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Ergonomics analysis of urological endoscopic surgery
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Development of novel ureteroscopic navigation system with a magnetic tracking device
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- 批准号:
25462530 - 财政年份:2013
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Analysis of laparoscopic dissection skill by instrument tip force measurement
器械尖端测力分析腹腔镜解剖技巧
- 批准号:
22591809 - 财政年份:2010
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of career education and employment support programs through collaborative support that utilizes the resources of universities
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- 批准号:
22531059 - 财政年份:2010
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Activation and regulation of the disease-related IL-6/STAT3 signaling
疾病相关 IL-6/STAT3 信号传导的激活和调节
- 批准号:
20390017 - 财政年份:2008
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Research on evaluation methods of urologic laparoscopic surgical skill
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- 批准号:
19591875 - 财政年份:2007
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Practical training at a special-needs high school using a university's resources
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- 批准号:
19530861 - 财政年份:2007
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Molecular mechanisms of STAT3 activation and their therapeutic applications
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- 批准号:
18390017 - 财政年份:2006
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
The effect of intrauterine inflammation on fetal cerebral hemodynamics and white matter injury in the chronically instrumented fetal sheep
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- 批准号:
18591213 - 财政年份:2006
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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