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The effect of fetal cerebral white matter injury on the development of oligodendroglial linages in chronically instrumented premature fetal sheep

The effect of fetal cerebral white matter injury on the development of oligodendroglial linages in chronically instrumented premature fetal sheep
胎儿脑白质损伤对长期仪器化早产胎羊少突胶质细胞系发育的影响
批准号:
21591407
负责人:
MATSUDA Tadashi
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
To determine the effect of cerebral ischemia and/or intrauterine inflammation on the development of oligodendroglial lineage in cerebral white matter, chronically instrumented fetal sheep was induced hemorrhagic hypotensionand/ornecrotizing funifitis. The brain was performed immunohistochemistry of NG2, O4, CNPase and PLP and then integrated density of each stain was statistically compared. The results suggested that in the premature fetal sheep, cerebral ischemia and/or intrauterine inflammation accelerated the oligodendroglial maturity from precursor to post-mitotic cells rather than induced apoptosis to precursor cells in the cerebral white matter.
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利用动物实验模型分析胚胎期器官成熟、适应和损伤
DOI: --
发表时间: 2009
期刊: 日未熟児新生児会誌
影响因子: --
作者: [渡辺達也, 松田直, 松田直]
通讯作者: 松田直
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [RyutaKitanishi, Tadashi Matsuda, Masatoshi Saito, TakushiHanita, Tatsuya Watanabe, Yoshiyasu Kobayashi, Nobuo Yaegashi]
通讯作者: Nobuo Yaegashi
新生児の慢性肺疾患.今日の治療指針2010版
新生儿慢性肺病今日治疗指南2010年版
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [西巻滋、島義雄, 安ひろみ、佐藤美保、岩崎志穂,岩崎志穂、堀口晴子堀口晴子、関和男、横田俊平横, 松田直, 松田直]
通讯作者: 松田直
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [RyutaKitanishi, Tadashi Matsuda, Masatoshi Saito, TakushiHanita, Tatsuya Watanabe, Yoshiyasu Kobayashi, Nobuo Yaegashi]
通讯作者: Nobuo Yaegashi
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