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Attachments of a Tip-Angling Device and a Working Channel : Development of the Multipurpose Ultrafine Spinal Fiberscope

Attachments of a Tip-Angling Device and a Working Channel : Development of the Multipurpose Ultrafine Spinal Fiberscope
尖端倾斜装置和工作通道的附件:多用途超细脊柱纤维镜的开发
批准号:
10557137
负责人:
SHIMOJI Koki
金额:
$7.74万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B).
财政年份:
1998
资助国家:
日本
项目状态:
已结题
起止时间:
1998 至 2000

项目摘要

项目成果

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中文摘要
翻译
本财政年度研究了用于记录生理事件、给药和手术干预等多用途的超细纤维镜的附着方法和工作通道。精细的柔性纤维镜使脊髓蛛网膜下腔的整个长度可视化成为可能。然而,进一步进入和干预椎管中的预期结构是不可能的,因为这样一个精细的纤维镜很难装备一个倾斜的装置和一个工作通道。在这里,我们开发了精细的柔性纤维镜(直径1.47和1.50 mm),配备了一个倾斜装置和一个工作通道。在9例疼痛患者和1例接受蛛网膜下腔膀胱切除术的患者中,使用纤维镜检查硬膜外和蛛网膜下腔间隙。硬膜外腔和蛛网膜下腔均易于接近和清晰可见,无重大并发症。6例患者纤维镜均可到达蛛网膜外腔。通过倾斜尖端,可以更清楚地观察到脐带的表面。在测试的5个病例中,有4个成功地将尖端精确定位到胸椎根。在硬膜外间隙操作过程中,4例患者出现根痛;经工作通道局部注射3ml 0.5%利多卡因后疼痛消失。在两例患者中,在逐步取出纤维镜的过程中,通过工作通道插入电极,成功地记录了硬膜外间隙的脊髓电位。因此,在疼痛患者的硬膜外和蛛网膜下腔的脊髓结构的经皮介入可以实现使用一个精细的柔性纤维镜的尖端倾斜装置和工作通道。
英文摘要
The methods for the attachments to the ultrafine fiberscope of a tip-angling device and a working channel of multipurpose uses, such as recording of physiological events, drug administrations and surgical interventions, were studied during this fiscal year.Fine flexible fiberscopes make it possible to visualize the entire length of the spinal subarachnoid space. However, further access and interventions to the intended structures in the spinal canal have been impossible because of the difficulty of equipping such a fine fiberscope with a tip-angling device and a working channel. Here, we developed fine flexible fiberscopes(1.47 and 1.50 mm in diameter)equipped with a tip-angling device and a working channel. Epidural and subarachnoid spaces were accessed with these fiberscopes in nine pain patients and one patient who underwent subarachnoid cystectomy. The epidural and subarachnoid spaces were easily approached and clearly visualized in all 10 patients without major complications. The fiberscope also reached the epiarachnoid space in all 6 cases tested. The surface of the cord was more clearly observed by angling the tip. Accurate positioning of the tip to a thoracic spinal root was successful in 4 of 5 cases tested. During manipulation of the epidural space, 4 patients noticed root pain ; this pain disappeared following regional injection of 3 ml of 0.5 % lidocaine through a working channel. In two patients, the spinal cord potential from the epidural space was successfully recorded using an electrode inserted through the working channel during step-by-step withdrawal of the fiberscope. Thus, percutaneous interventions to the spinal structures in the epidural and subarachnoid spaces of the pain patients can be achieved using a fine flexible fiberscope with a tip-angling device and a working channel.
期刊论文(88)
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会议论文
Yamakura T他: "Sensitivity of the N-methl-D-asparte receptor channel tobutyrophenones is dependent on the ε_2 subunit" Neurophamacology. 37.6. 709-717 (1998)
Yamakura T 等人:“N-甲基-D-天冬氨酸受体通道苯丁酰苯的敏感性取决于 ε_2 亚基”Neurophamacology 37.6 (1998)。
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通讯作者:
Ataka T, Okamoto M, Kohno T, Baba H, Shimoji K: "Midazolam enhances GABAA-induced inhibitory effects in substantia gelationosa in rat spinal cord."J Electrodiagnosis Spnal Cord. 20(1). 9-12 (1998)
Ataka T、Okamoto M、Kohno T、Baba H、Shimoji K:“咪达唑仑增强 GABAA 诱导的大鼠脊髓凝胶质的抑制作用。”J Electrodiagnosis Spnal Cord。
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通讯作者:
Kohno T, Kumamoto E, Higashi H, Shimoji K, yoshimura M: "Actions of opioids on excitatory and inhibitory transmission in substantia gelatinosa of adult rat spinal cord."J Physiol. 518(3). 803-813 (1999)
Kohno T、Kumamoto E、Higashi H、Shimoji K、yoshimura M:“阿片类药物对成年大鼠脊髓胶质质兴奋性和抑制性传递的作用。”J Physiol。
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通讯作者:
飛田俊幸, 他: "術中脊髄機能モニタリングの現況と問題点"臨床脳波. 42・6. 347-352 (2000)
Toshiyuki Tobita等:“术中脊髓功能监测的现状和问题”临床脑电图42・6(2000)。
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44
    Molecular and Physiological Bases of Endogenous Cerebral Anti-ischemic Mechanisms and Their Applications to Treatments of Brain Ischemia
    • 批准号:
      10307035
    • 项目类别:
      Grant-in-Aid for Scientific Research (A).
    • 资助金额:
      $16.26万
    • 财政年份:
      1998
    • 负责人:
      SHIMOJI Koki
    • 依托单位:
    Development of a monitoring system for blood flow and metabolism in subarachnoid and epidural tissues using a micro fiberscope
    • 批准号:
      07557100
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $8.64万
    • 财政年份:
      1995
    • 负责人:
      SHIMOJI Koki
    • 依托单位:
    Research on intrinsic anti-ischemic mechanisms : From the standpoint of cell membrane and receptor channel mechanisms
    • 批准号:
      06404055
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $22.08万
    • 财政年份:
      1994
    • 负责人:
      SHIMOJI Koki
    • 依托单位:
    Experimental study on the mechanism of pain induction in the reflex sympathetic dystrophy
    • 批准号:
      04454385
    • 项目类别:
      Grant-in-Aid for General Scientific Research (B)
    • 资助金额:
      $3.78万
    • 财政年份:
      1992
    • 负责人:
      SHIMOJI Koki
    • 依托单位:
    国内基金
    海外基金
    PICH蛋白处理超细后期桥(ultrafine anaphasebridge)的分子机制
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    • 资助金额:
      15.0万元
    • 批准年份:
      2024
    • 负责人:
      陈英伟
    • 依托单位:
    RIF1蛋白在处理超细后期桥(ultrafine anaphase bridge)和保障基因组稳定的作用
    • 批准号:
    • 项目类别:
      省市级项目
    • 资助金额:
      10.0万元
    • 批准年份:
      2019
    • 负责人:
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    • 依托单位: