Attachments of a Tip-Angling Device and a Working Channel : Development of the Multipurpose Ultrafine Spinal Fiberscope

尖端倾斜装置和工作通道的附件:多用途超细脊柱纤维镜的开发

基本信息

  • 批准号:
    10557137
  • 负责人:
  • 金额:
    $ 7.74万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B).
  • 财政年份:
    1998
  • 资助国家:
    日本
  • 起止时间:
    1998 至 2000
  • 项目状态:
    已结题

项目摘要

The methods for the attachments to the ultrafine fiberscope of a tip-angling device and a working channel of multipurpose uses, such as recording of physiological events, drug administrations and surgical interventions, were studied during this fiscal year.Fine flexible fiberscopes make it possible to visualize the entire length of the spinal subarachnoid space. However, further access and interventions to the intended structures in the spinal canal have been impossible because of the difficulty of equipping such a fine fiberscope with a tip-angling device and a working channel. Here, we developed fine flexible fiberscopes(1.47 and 1.50 mm in diameter)equipped with a tip-angling device and a working channel. Epidural and subarachnoid spaces were accessed with these fiberscopes in nine pain patients and one patient who underwent subarachnoid cystectomy. The epidural and subarachnoid spaces were easily approached and clearly visualized in all 10 patients without major complications. The fiberscope also reached the epiarachnoid space in all 6 cases tested. The surface of the cord was more clearly observed by angling the tip. Accurate positioning of the tip to a thoracic spinal root was successful in 4 of 5 cases tested. During manipulation of the epidural space, 4 patients noticed root pain ; this pain disappeared following regional injection of 3 ml of 0.5 % lidocaine through a working channel. In two patients, the spinal cord potential from the epidural space was successfully recorded using an electrode inserted through the working channel during step-by-step withdrawal of the fiberscope. Thus, percutaneous interventions to the spinal structures in the epidural and subarachnoid spaces of the pain patients can be achieved using a fine flexible fiberscope with a tip-angling device and a working channel.
本财年,研究了尖端倾斜装置的超细纤维镜附件和多用途工作通道的方法,例如记录生理事件、药物管理和外科手术。精细柔性纤维镜使整个长度的脊柱蛛网膜下腔可视化成为可能。然而,由于很难为这种细纤维镜配备尖端倾斜装置和工作通道,因此不可能进一步接近和干预椎管内的预期结构。在这里,我们开发了配备尖端倾斜装置和工作通道的精细柔性纤维镜(直径 1.47 和 1.50 毫米)。在九名疼痛患者和一名接受蛛网膜下腔囊肿切除术的患者中,使用这些纤维镜进入硬膜外和蛛网膜下腔。所有 10 名患者的硬膜外腔和蛛网膜下腔均易于接近且清晰可见,且无严重并发症。在所有 6 例测试的病例中,纤维镜均到达蛛网膜外腔。通过调整尖端的角度可以更清楚地观察绳索的表面。在测试的 5 例病例中,有 4 例成功将尖端准确定位到胸椎根部。在硬膜外腔操作过程中,4 名患者出现根部疼痛;通过工作通道局部注射 3 毫升 0.5% 利多卡因后,这种疼痛消失。在两名患者中,在逐步撤回纤维镜期间,使用通过工作通道插入的电极成功记录了硬膜外腔的脊髓电位。因此,可以使用带有尖端倾斜装置和工作通道的精细柔性纤维镜来对疼痛患者的硬膜外腔和蛛网膜下腔中的脊柱结构进行经皮干预。

项目成果

期刊论文数量(88)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Yamakura T他: "Sensitivity of the N-methl-D-asparte receptor channel tobutyrophenones is dependent on the ε_2 subunit" Neurophamacology. 37.6. 709-717 (1998)
Yamakura T 等人:“N-甲基-D-天冬氨酸受体通道苯丁酰苯的敏感性取决于 ε_2 亚基”Neurophamacology 37.6 (1998)。
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    0
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Ataka T, Okamoto M, Kohno T, Baba H, Shimoji K: "Midazolam enhances GABAA-induced inhibitory effects in substantia gelationosa in rat spinal cord."J Electrodiagnosis Spnal Cord. 20(1). 9-12 (1998)
Ataka T、Okamoto M、Kohno T、Baba H、Shimoji K:“咪达唑仑增强 GABAA 诱导的大鼠脊髓凝胶质的抑制作用。”J Electrodiagnosis Spnal Cord。
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    0
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Kohno T, Kumamoto E, Higashi H, Shimoji K, yoshimura M: "Actions of opioids on excitatory and inhibitory transmission in substantia gelatinosa of adult rat spinal cord."J Physiol. 518(3). 803-813 (1999)
Kohno T、Kumamoto E、Higashi H、Shimoji K、yoshimura M:“阿片类药物对成年大鼠脊髓胶质质兴奋性和抑制性传递的作用。”J Physiol。
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    0
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飛田俊幸, 他: "術中脊髄機能モニタリングの現況と問題点"臨床脳波. 42・6. 347-352 (2000)
Toshiyuki Tobita等:“术中脊髓功能监测的现状和问题”临床脑电图42・6(2000)。
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    0
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Belova OA, Uchiyama S, Yajiri Y, Takahashi HE, Shimoji K: "Spinal cord monitoring in spinal surgery : two demonstrative cases."Acta Med Biol. 47(2). 81-84 (1999)
Belova OA、Uchiyama S、Yajiri Y、Takahashi HE、Shimoji K:“脊柱手术中的脊髓监测:两个示范病例。”Acta Med Biol。
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SHIMOJI Koki其他文献

SHIMOJI Koki的其他文献

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{{ truncateString('SHIMOJI Koki', 18)}}的其他基金

Molecular and Physiological Bases of Endogenous Cerebral Anti-ischemic Mechanisms and Their Applications to Treatments of Brain Ischemia
脑内源性抗缺血机制的分子和生理基础及其在脑缺血治疗中的应用
  • 批准号:
    10307035
  • 财政年份:
    1998
  • 资助金额:
    $ 7.74万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A).
Development of a monitoring system for blood flow and metabolism in subarachnoid and epidural tissues using a micro fiberscope
使用微型纤维镜开发蛛网膜下腔和硬膜外组织血流和代谢监测系统
  • 批准号:
    07557100
  • 财政年份:
    1995
  • 资助金额:
    $ 7.74万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Research on intrinsic anti-ischemic mechanisms : From the standpoint of cell membrane and receptor channel mechanisms
内在抗缺血机制研究:从细胞膜和受体通道机制的角度
  • 批准号:
    06404055
  • 财政年份:
    1994
  • 资助金额:
    $ 7.74万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Experimental study on the mechanism of pain induction in the reflex sympathetic dystrophy
反射性交感神经营养不良疼痛诱发机制的实验研究
  • 批准号:
    04454385
  • 财政年份:
    1992
  • 资助金额:
    $ 7.74万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
Pathophysiology and treatments of brain ischemia insighted from neuronal function, metabolism and molecular structure
从神经元功能、代谢和分子结构洞察脑缺血的病理生理学和治疗
  • 批准号:
    04304042
  • 财政年份:
    1992
  • 资助金额:
    $ 7.74万
  • 项目类别:
    Grant-in-Aid for Co-operative Research (A)
Development of fine fiberscope system for fluorescence observation of epidural and subarachnoid spaces
开发用于硬膜外和蛛网膜下腔荧光观察的细纤维镜系统
  • 批准号:
    02557058
  • 财政年份:
    1990
  • 资助金额:
    $ 7.74万
  • 项目类别:
    Grant-in-Aid for Developmental Scientific Research (B)
Induction and Identification of Endogenous Anti-Ischemic Mechanisms (Factors)
内源性抗缺血机制(因子)的诱导和鉴定
  • 批准号:
    63440058
  • 财政年份:
    1988
  • 资助金额:
    $ 7.74万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (A)
DEVELOPMENTS OF FINE FIBERSCOPES AND IMAGE-ENHANCEMENT SYSTEM FOR EPIDURAL AND SUBARACHNOID SPACES
硬膜外和蛛网膜下腔精细纤维镜和图像增强系统的开发
  • 批准号:
    62870064
  • 财政年份:
    1987
  • 资助金额:
    $ 7.74万
  • 项目类别:
    Grant-in-Aid for Developmental Scientific Research
Study on pathophysiology of cerebral hypoxia by means of the brain slice technique and the regional perfusion technique
脑切片技术和局部灌注技术研究脑缺氧的病理生理学
  • 批准号:
    60480345
  • 财政年份:
    1985
  • 资助金额:
    $ 7.74万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
Development of the system and electrode for simultaneous measurements of regional blood flow, oxygen pressure and activity
开发用于同时测量局部血流、氧压和活动的系统和电极
  • 批准号:
    59870051
  • 财政年份:
    1984
  • 资助金额:
    $ 7.74万
  • 项目类别:
    Grant-in-Aid for Developmental Scientific Research

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Household Air Pollution, Adiposity, and Cardiorenal Disease Risk in Children
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Challenging research to development oral vaccines (biopharmaceuticals) with innovative material ultrafine bubbles
采用创新材料超细气泡开发口服疫苗(生物制药)的挑战性研究
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Dissecting the Role of Arachidonic Acid Metabolic Pathways Involved in Resolution Versus Progression of PM-Induced Cardiometabolic Toxicity
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